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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt3tm1Irl
targeted mutation 1, Ihor R Lemischka
MGI:2384051
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flt3tm1Irl/Flt3tm1Irl either: 129S/SvEv-Flt3tm1Irl or (involves: 129S/SvEv * C57BL/6J) MGI:2683905
cx2
 		Flt3tm1Irl/Flt3tm1Irl
KitW/KitW-v 		involves: 129S/SvEv * C57BL/6 MGI:3663023


Genotype
MGI:2683905
hm1
Allelic
Composition		 Flt3tm1Irl/Flt3tm1Irl
Genetic
Background		 either: 129S/SvEv-Flt3tm1Irl or (involves: 129S/SvEv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1Irl mutation (4 available); any Flt3 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:27238 , J:99149 )
• percentage of bone marrow B220+ cells is reduced (J:27238)
• Background Sensitivity: 10 fold reduction of primitive B lymphoid progenitors is less severe on a mixed background than on an inbred 129S/SvEv background (J:27238)
• early T lineage precursors lose the ability generate B cells (J:99149)
decreased pro-B cell number ( J:27238 )
• significantly reduced pro-B cell numbers, 49% normal
decreased pre-B cell number ( J:27238 )
• moderately reduced in numbers, 74% normal

hematopoietic system
abnormal B cell differentiation ( J:27238 , J:99149 )
• percentage of bone marrow B220+ cells is reduced (J:27238)
• Background Sensitivity: 10 fold reduction of primitive B lymphoid progenitors is less severe on a mixed background than on an inbred 129S/SvEv background (J:27238)
• early T lineage precursors lose the ability generate B cells (J:99149)
decreased pro-B cell number ( J:27238 )
• significantly reduced pro-B cell numbers, 49% normal
decreased pre-B cell number ( J:27238 )
• moderately reduced in numbers, 74% normal




Genotype
MGI:3663023
cx2
Allelic
Composition		 Flt3tm1Irl/Flt3tm1Irl
KitW/KitW-v
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1Irl mutation (4 available); any Flt3 mutation (90 available)
KitW mutation (10 available); any Kit mutation (182 available)
KitW-v mutation (10 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:27238 )
• slightly reduced body weight

hematopoietic system
abnormal common myeloid progenitor cell morphology ( J:27238 )
• absolute numbers of myeloid progenitors reduced 8 fold
abnormal myelopoiesis ( J:27238 )
• myeloid lineages are reduced in numbers
decreased bone marrow cell number ( J:27238 )
• reduced cellularity
decreased pro-B cell number ( J:27238 )
• greater reduction in numbers
abnormal T cell number ( J:27238 )
• proportion of CD4 and CD8 single positive T cells is increased 2 fold
• absolute numbers of single positive cells reduced 4 fold
decreased double-negative T cell number ( J:27238 )
• severely restricted in numbers
decreased double-positive T cell number ( J:27238 )
• severely restricted in numbers
decreased lymphocyte cell number ( J:27238 )
• lymphoid lineages are reduced in numbers
decreased B cell number ( J:27238 )
• 10% reduction
• absolute numbers reduced 16%
decreased pre-B cell number ( J:27238 )
• greater reduction

immune system
abnormal myelopoiesis ( J:27238 )
• myeloid lineages are reduced in numbers
decreased pro-B cell number ( J:27238 )
• greater reduction in numbers
abnormal T cell number ( J:27238 )
• proportion of CD4 and CD8 single positive T cells is increased 2 fold
• absolute numbers of single positive cells reduced 4 fold
decreased double-negative T cell number ( J:27238 )
• severely restricted in numbers
decreased double-positive T cell number ( J:27238 )
• severely restricted in numbers
decreased lymphocyte cell number ( J:27238 )
• lymphoid lineages are reduced in numbers
decreased B cell number ( J:27238 )
• 10% reduction
• absolute numbers reduced 16%
decreased pre-B cell number ( J:27238 )
• greater reduction

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory