homeostasis/metabolism
• 6.5 fold reduction in serum iron levels at 16 months
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• lowered transferrin saturation
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• total non-heme iron accumulation in the brainstem increased 103%
(J:78092)
• total non-heme iron accumulation in the cerebellum increased 35% at 16 months
(J:78092)
• total non-heme iron accumulation in the cervical spinal cord increased 116%
(J:78092)
• total non-heme iron accumulation in the thoracic spinal cord increased 84%
(J:78092)
• total non-heme iron accumulation in the retina increased 93%
(J:78092)
• no iron accumulation in the cerebellum at 6 months
(J:112703)
|
• 10.6 fold increase at 16 months
|
• lipid peroxidation elevated by 84% in the olfactory bulb at 16 months
• lipid peroxidation elevated by 58% in the cervical spinal cord at 16 months
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• spinal cord contusion injury in 2-4 month old mice results in a 4.9 fold increase in iron levels at the site of injury compared to 3.2 fold for injured controls
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nervous system
• total non-heme iron accumulation in the brainstem increased 103%
(J:78092)
• total non-heme iron accumulation in the cerebellum increased 35% at 16 months
(J:78092)
• total non-heme iron accumulation in the cervical spinal cord increased 116%
(J:78092)
• total non-heme iron accumulation in the thoracic spinal cord increased 84%
(J:78092)
• total non-heme iron accumulation in the retina increased 93%
(J:78092)
• no iron accumulation in the cerebellum at 6 months
(J:112703)
|
• two fold increase in iron accumulation in cells adjacent to the lining of the fourth ventricle at 12 months
• 4.5 fold increase in iron accumulation in cells adjacent to the lining of the fourth ventricle at 24 months
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• iron deposition is particularly located in the granule cell layer and deep cerebellar nuclei
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• loss of astrocytes by 24 months of age
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• no iron accumulation in Purkinje cells
• loss of Purkinje cells by 12 to 24 months
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• motor neuron loss after spinal cord contusion is two fold greater near the site of injury than in injured controls
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• loss of tyrosine hydroxylase positive dopamineric neurons in the brainstem by 16 months
• cultured cerebellar neurons display increased susceptibility to free radical damage when treated with lower concentrations of hydrogen peroxide
• free radical damage of cultured neurons offset by treatment with iron chelators
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• iron efflux of cultured astrocytes is about 5% as opposed to 70% for controls over a 48 hour period
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• 44% greater loss of myelin in white matter after spinal cord contusion than in injured controls
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liver/biliary system
• 10.6 fold increase at 16 months
|
behavior/neurological
• reduced ability of 16 month old homozygotes to maintain their balance on a rotarod
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• locomotor function is significantly impaired 5 days after spinal cord contusion as compared to injured controls
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vision/eye
• neurodegeneration in the inner nuclear layer of the retina by 16 months
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cellular
• cultured cerebellar neurons display increased susceptibility to free radical damage when treated with lower concentrations of hydrogen peroxide
• free radical damage of cultured neurons offset by treatment with iron chelators
|