All Phenotypes Syk<tm1Tyb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Syk^tm1Tyb
targeted mutation 1, Victor L J Tybulewicz
MGI:2384078

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syk^tm1Tyb/Syk^tm1Tyb	involves: 129S2/SvPas	MGI:3841128
hm2	Syk^tm1Tyb/Syk^tm1Tyb	involves: 129S2/SvPas * C57BL/6	MGI:3818499
hm3	Syk^tm1Tyb/Syk^tm1Tyb	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3056633
hm4	Syk^tm1Tyb/Syk^tm1Tyb	involves: 129S2/SvPas * C57BL/6J	MGI:5314241
cn5	Itgam^tm1Myd/Itgam^tm1Myd Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4415250
cn6	Syk^tm1Tyb/Syk^tm1.2Tara Tg(S100A8-cre,-EGFP)1Ilw/0	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6	MGI:4415251
cn7	Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4415249

Allelic Composition	Syk^tm1Tyb/Syk^tm1Tyb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:155479 )

• neutrophils exhibit impaired degranulation in response to bacteria compared with wild-type cells

• bacteria-stimulated neutrophils exhibit altered cytokine profiles and secret less TNF-alpha compared with similarly treated wild-type cells

• bacteria-bound neutrophils exhibit less superoxidation than similarly treated wild-type cells

impaired neutrophil phagocytosis ( J:155479 )

• neutrophils exhibit reduced S. aureus phagocytosis and modest reductions in E. coli phagocytosis compared with similarly treated wild-type cells

impaired granulocyte bactericidal activity ( J:155479 )

• neutrophils exhibit reduced killing of S. aureus and modest reductions in the killing of E. coli compared with similarly treated wild-type cells

abnormal dendritic cell antigen presentation ( J:147472 )

• CD8alpha⁺ dendritic cells have a specific defect in efficient cross-presentation of dead-cell associated antigens

• CD8alpha⁺ dendritic cells are able to uptake necrotic cells, present soluble antigen, and present antigen conjugated to beads (a model of cross presentation)

decreased tumor necrosis factor secretion ( J:155479 )

• bacteria-stimulated neutrophils secret less TNF-alpha compared with similarly treated wild-type cells

hematopoietic system

abnormal neutrophil physiology ( J:155479 )

• neutrophils exhibit impaired degranulation in response to bacteria compared with wild-type cells

• bacteria-stimulated neutrophils exhibit altered cytokine profiles and secret less TNF-alpha compared with similarly treated wild-type cells

• bacteria-bound neutrophils exhibit less superoxidation than similarly treated wild-type cells

impaired neutrophil phagocytosis ( J:155479 )

• neutrophils exhibit reduced S. aureus phagocytosis and modest reductions in E. coli phagocytosis compared with similarly treated wild-type cells

impaired granulocyte bactericidal activity ( J:155479 )

• neutrophils exhibit reduced killing of S. aureus and modest reductions in the killing of E. coli compared with similarly treated wild-type cells

cellular

impaired neutrophil phagocytosis ( J:155479 )

• neutrophils exhibit reduced S. aureus phagocytosis and modest reductions in E. coli phagocytosis compared with similarly treated wild-type cells

Allelic Composition	Syk^tm1Tyb/Syk^tm1Tyb
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation

decreased bone resorption ( J:89583 )

• osteoclast fail to resorb mineralized matrix in vivo unlike wild-type cells

• neither treatment of osteoclast precursors with large doses of macrophage colony stimulating factor nor coculture with wild-type osteoblasts can rescue bone resoprtion

• however, transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore bone resoption

immune system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

hematopoietic system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

cellular

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

Allelic Composition	Syk^tm1Tyb/Syk^tm1Tyb
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:29796 )

• only 1 of 227 mice at 10-20 days of age was a homozygote

neonatal lethality, incomplete penetrance ( J:29796 )

• many homozygotes die shortly after birth

cardiovascular system

hemorrhage ( J:29796 )

• at E16.5 extensive hemorrhaging is seen in all homozygotes but by E18.5 hemorrages are seen in only 45% of homozygotes

immune system

arrested B cell differentiation ( J:29796 )

• at 2 days of age no IgM+ B cells are found in the spleen and cultured fetal liver cells fail to produce IgM+ B cells

• radiation chimeras reconstituted with homozygous fetal liver cells have virtually no mature B cells and reduced numbers of pre-B cells

abnormal T cell number ( J:29796 )

• at E16.5 and E18.5 the number of mature Vgamma3+ thymocytes is reduced or undetectable; however in radiation chimeras the numbers of CD4+ and CD8+ T cells is similar to wild-type

• T cell numbers in the skin are reduced to about 60% of wild-type

homeostasis/metabolism

chylous ascites ( J:29796 )

• chylous ascites are seen after pups begin feeding

hematopoietic system

arrested B cell differentiation ( J:29796 )

• at 2 days of age no IgM+ B cells are found in the spleen and cultured fetal liver cells fail to produce IgM+ B cells

• radiation chimeras reconstituted with homozygous fetal liver cells have virtually no mature B cells and reduced numbers of pre-B cells

abnormal T cell number ( J:29796 )

• at E16.5 and E18.5 the number of mature Vgamma3+ thymocytes is reduced or undetectable; however in radiation chimeras the numbers of CD4+ and CD8+ T cells is similar to wild-type

• T cell numbers in the skin are reduced to about 60% of wild-type

Allelic Composition	Syk^tm1Tyb/Syk^tm1Tyb
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:181715 )

• at P0, lymphatic vessels in the lungs contain blood cells unlike in wild-type mice

• mice exhibit a connection between the vasculature and lymphatic systems

decreased lymphatic vessel endothelial cell number ( J:181715 )

• the ratio of lymphatic endothelial cells to blood endothelial cells is reduced in the lungs compared to in control mice

cardiovascular system

abnormal brain vasculature morphology ( J:181715 )

• mice exhibit a connection between the vasculature and lymphatic systems unlike in wild-type mice

intracranial hemorrhage ( J:181715 )

• in the brain (parenchyma) at E12.5 persisting through E18.5

spinal hemorrhage ( J:181715 )

• at E12.5 persisting through E18.5

respiratory system

abnormal lung morphology ( J:181715 )

• larger airways contain fluid droplets unlike in control mice

primary atelectasis ( J:181715 )

• some terminal air sacs fail to properly inflate

nervous system

abnormal brain vasculature morphology ( J:181715 )

• mice exhibit a connection between the vasculature and lymphatic systems unlike in wild-type mice

intracranial hemorrhage ( J:181715 )

• in the brain (parenchyma) at E12.5 persisting through E18.5

spinal hemorrhage ( J:181715 )

• at E12.5 persisting through E18.5

Allelic Composition	Itgam^tm1Myd/Itgam^tm1Myd Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgam^tm1Myd mutation (1 available); any Itgam mutation (48 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice

Allelic Composition	Syk^tm1Tyb/Syk^tm1.2Tara Tg(S100A8-cre,-EGFP)1Ilw/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)
Tg(S100A8-cre,-EGFP)1Ilw mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

Allelic Composition	Syk^tm1Tyb/Syk^tm1.2Tara Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Syk^tm1Tyb mutation (0 available); any Syk mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal neutrophil physiology ( J:155479 )

• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

hematopoietic system

abnormal neutrophil physiology ( J:155479 )

• migration of neutrophils to the cite of bacterial infection is enhanced compared to in similarly treated wild-type mice

impaired granulocyte bactericidal activity ( J:155479 )

• S. aureus-infected mice exhibit a 3- to 4-fold increased in viable S. aureus compared to in similarly treated wild-type mice

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