Phenotypes associated with this allele

• Allele Symbol: Fgg^tm1Jld
• Allele Name: targeted mutation 1, Jay L Degen
• Allele ID: MGI:2384081
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgg^tm1Jld/Fgg^tm1Jld	involves: 129P2/OlaHsd * NIH Black Swiss	MGI:3663012

Genotype
MGI:3663012

hm1

• Allelic Composition: Fgg^tm1Jld/Fgg^tm1Jld
• Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet aggregation ( J:36873 )

• homozygotes display a generally normal hematological profile, including normal platelet count, plasma fibrinogen level, clotting time and fibrin crosslinking

• however, in vitro, plasma suspensions from mutant mice fail to exhibit ADP (or collagen)-induced platelet aggregation, despite an observable platelet shape change

• addition of either normal mouse plasma or purified mouse fibrinogen restores platelet aggregation, regardless of the agonist used

homeostasis/metabolism

decreased platelet aggregation ( J:36873 )

• homozygotes display a generally normal hematological profile, including normal platelet count, plasma fibrinogen level, clotting time and fibrin crosslinking

• however, in vitro, plasma suspensions from mutant mice fail to exhibit ADP (or collagen)-induced platelet aggregation, despite an observable platelet shape change

• addition of either normal mouse plasma or purified mouse fibrinogen restores platelet aggregation, regardless of the agonist used

increased bleeding time ( J:36873 )

• homozygotes exhibit significantly increased bleeding times following a standard injury to the nail bed on the 5th digit of the hindleg relative to wild-type mice (>25 min vs ~5 min, respectively)

• however, homozygotes are able to control bleeding at other sites of injury that involve small blood vessels, such as a 1.3 cm full-thickness skin incision

cardiovascular system

hemoperitoneum ( J:36873 )

• homozygotes that survive to weaning show no overt or microscopic defects in any major organ system or incidences of bleeding, illness or death up to 4 months of age

• female homozygotes are fertile and do not exhibit fatal intrauterine hemorrhage during pregnancy

• however, 4 of 173 (2.3%) of neonatal homozygotes display spontaneous, fatal bleeding into the peritoneal cavity; in one case, the source of bleeding is a ruptured blood vessel within the distended stomach