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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd3etm1.1Lov
targeted mutation 1.1, Paul E Love
MGI:2384123
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd3etm1.1Lov/Cd3etm1.1Lov Not Specified MGI:3691086
cx2
 		Cd3etm1.1Lov/Cd3etm1.1Lov
Trdctm1Mal/Trdctm1Mal 		involves: C57BL/6 MGI:3690997


Genotype
MGI:3691086
hm1
Allelic
Composition		 Cd3etm1.1Lov/Cd3etm1.1Lov
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1.1Lov mutation (0 available); any Cd3e mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell morphology ( J:72144 )
• single positive (SP) thymocytes are absent
• mature SP T cells are absent from periphery
• alpha/beta and gamma/delta TCR complexes are undetectable in thymus and lymphoid organs
increased double-negative T cell number ( J:72144 )
• all thymocytes present are DN
decreased double-positive T cell number ( J:72144 )
• DP thymocytes are absent
arrested T cell differentiation ( J:72144 )
• development is arrested at CD44-/lo stage

immune system
abnormal T cell morphology ( J:72144 )
• single positive (SP) thymocytes are absent
• mature SP T cells are absent from periphery
• alpha/beta and gamma/delta TCR complexes are undetectable in thymus and lymphoid organs
increased double-negative T cell number ( J:72144 )
• all thymocytes present are DN
decreased double-positive T cell number ( J:72144 )
• DP thymocytes are absent
arrested T cell differentiation ( J:72144 )
• development is arrested at CD44-/lo stage




Genotype
MGI:3690997
cx2
Allelic
Composition		 Cd3etm1.1Lov/Cd3etm1.1Lov
Trdctm1Mal/Trdctm1Mal
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1.1Lov mutation (0 available); any Cd3e mutation (54 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:112658 )
• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells
• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells

immune system
abnormal double-negative T cell morphology ( J:112658 )
• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells
• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory