Phenotypes associated with this allele

• Allele Symbol: Plp1^tm1Wst
• Allele Name: targeted mutation 1, Wilhelm Stoffel
• Allele ID: MGI:2384125
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plp1^tm1Wst/Plp1^tm1Wst	involves: 129P2/OlaHsd	MGI:3620192
ht2	Plp1^tm1Wst/Plp1^+	involves: 129P2/OlaHsd	MGI:3620193

Genotype
MGI:3620192

hm1

• Allelic Composition: Plp1^tm1Wst/Plp1^tm1Wst
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal oligodendrocyte morphology ( J:21976 )

♀ • oligodendrocyte plasma membrane processes are only wrapped around large diameter axons and no contact is made between the plasma membrane and the axon

abnormal axon morphology ( J:105188 )

♀ • abnormal accumulation of organelles

abnormal myelin sheath morphology ( J:105188 )

♀ • myelin sheaths are not compacted, and myelin sheaths with remaining oligodendrocyte cytoplasm are detected

axonal spheroids ( J:105188 )

♀

abnormal myelination ( J:21976 , J:105188 )

♀ • small diameter axons are not myelinated (J:21976)

♀ • small diameter axons are hypomyelinated (J:105188)

abnormal nerve conduction ( J:21976 )

♀ • optic nerve conductance velocity is about half that of wild-type mice

behavior/neurological

impaired coordination ( J:21976 )

♀ • homozygotes fall off a rotating rod sooner and at lower rates of revolution

decreased locomotor activity ( J:21976 )

♀ • activity, especially horizontal activity, is reduced in an open field

Genotype
MGI:3620193

ht2

• Allelic Composition: Plp1^tm1Wst/Plp1⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal oligodendrocyte morphology ( J:21976 )

♀ • a mosaic of normally myelinated axons and axons abnormally surrounded by oligodendrocyte membranes (similar to homozygous mice) is seen