Phenotypes associated with this allele

• Allele Symbol: Plp1^tm2Wst
• Allele Name: targeted mutation 2, Wilhelm Stoffel
• Allele ID: MGI:2384127
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plp1^tm2Wst/Plp1^tm2Wst	involves: 129P2/OlaHsd	MGI:3620194
ht2	Plp1^tm2Wst/Plp1^+	involves: 129P2/OlaHsd	MGI:3620195

Genotype
MGI:3620194

hm1

• Allelic Composition: Plp1^tm2Wst/Plp1^tm2Wst
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal oligodendrocyte morphology ( J:21976 )

♀ • oligodendrocyte plasma membrane processes are only wrapped around large diameter axons and no contact is made between the plasma membrane and the axon

abnormal myelination ( J:21976 )

♀ • small diameter axons are not myelinated

abnormal nerve conduction ( J:21976 )

♀ • optic nerve conductance velocity is about half that of wild-type mice

behavior/neurological

impaired coordination ( J:21976 )

♀ • homozygotes fall off a rotating rod sooner and at lower rates of revolution

decreased locomotor activity ( J:21976 )

♀ • activity, especially horizontal activity, is reduced in an open field

Genotype
MGI:3620195

ht2

• Allelic Composition: Plp1^tm2Wst/Plp1⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal oligodendrocyte morphology ( J:21976 )

♀ • a mosaic of normally myelinated axons and axons abnormally surrounded by oligodendrocyte membranes (similar to homozygous mice) is seen