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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Frat1tm1Brn
targeted mutation 1, Anton Berns
MGI:2384128
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Frat1tm1Brn/Frat1tm1Brn either: (involves: 129P/Ola * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB) MGI:2686874
cx2
 		Frat1tm1Brn/Frat1tm1Brn
Frat2tm2Brn/Frat2tm2Brn
Peg12tm1Brn/Peg12tm1Brn 		involves: 129P2/OlaHsd * FVB MGI:3530548


Genotype
MGI:2686874
hm1
Allelic
Composition		 Frat1tm1Brn/Frat1tm1Brn
Genetic
Background		 either: (involves: 129P/Ola * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frat1tm1Brn mutation (2 available); any Frat1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:58550 )
• no notable differences in size, behavior, life span and reproductive capabilities are seen
• no abnormalities in the major organ systems are seen by histological analysis
• normal size and architecture of lymphoid organs including bone marrow, thymus, spleen, and lymph nodes




Genotype
MGI:3530548
cx2
Allelic
Composition		 Frat1tm1Brn/Frat1tm1Brn
Frat2tm2Brn/Frat2tm2Brn
Peg12tm1Brn/Peg12tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frat1tm1Brn mutation (2 available); any Frat1 mutation (9 available)
Frat2tm2Brn mutation (1 available); any Frat2 mutation (11 available)
Peg12tm1Brn mutation (1 available); any Peg12 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:96034 )
• triple homozygotes are healthy and fertile and have normal lymphocyte development, mature B and T cell numbers, and intestinal epithelium

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT Prader-Willi syndrome DOID:11983 OMIM:176270
 J:96034




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory