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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk8tm1Wag
targeted mutation 1, Erwin F Wagner
MGI:2384141
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk8tm1Wag/Mapk8tm1Wag B6.129P2-Mapk8tm1Wag MGI:3619043
hm2
 		Mapk8tm1Wag/Mapk8tm1Wag involves: 129P2/OlaHsd MGI:3619036
hm3
 		Mapk8tm1Wag/Mapk8tm1Wag involves: 129P2/OlaHsd * C57BL/6 MGI:6450933
cn4
 		Krastm4Tyj/Kras+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4948963
cx5
 		Lepob/Lepob
Mapk8tm1Wag/Mapk8tm1Wag 		B6.Cg-Lepob Mapk8tm1Wag MGI:3619044
cx6
 		Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+ 		involves: 129 MGI:3619037
cx7
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+ 		involves: 129 MGI:3619038
cx8
 		Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129 MGI:3619039
cx9
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+ 		involves: 129 * C57BL/6 MGI:3619041
cx10
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129 * C57BL/6 MGI:3619040
cx11
 		Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka 		involves: 129 * C57BL/6 MGI:3619042
cx12
 		Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8tm1Wag 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 MGI:6384031
cx13
 		Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 MGI:6384032
cx14
 		Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+ 		involves: 129/Sv * 129P2/OlaHsd MGI:4948961


Genotype
MGI:3619043
hm1
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Genetic
Background		 B6.129P2-Mapk8tm1Wag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to diet-induced obesity ( J:80452 )
• on a high fat high calorie diet homozygotes do not gain as much weight as wild-type mice however, on a normal diet body weight is similar to wild-type
decreased circulating glucose level ( J:80452 )
• on a high fat high calorie diet blood glucose is decreased compared to wild-type controls
decreased circulating insulin level ( J:80452 )
• on a high fat high calorie diet blood insulin is decreased compared to wild-type controls
improved glucose tolerance ( J:80452 )
• on a high fat high calorie diet glucose tolerance is improved compared to wild-type controls
• glucose tolerance is also improved in homozygotes on a normal diet
increased insulin sensitivity ( J:80452 )
• on a high fat high calorie diet insulin sensitivity is increased compared to wild-type controls

adipose tissue
decreased subcutaneous adipose tissue amount ( J:80452 )
• on a high fat high calorie diet the weight of the subcutaneous fat depot is reduced by 33% compared to wild-type
decreased total body fat amount ( J:80452 )
• on a high fat high calorie diet total body adiposity is decreased compared to wild-type
abnormal fat cell morphology ( J:80452 )
• on a high fat high calorie diet adipocytes are smaller compared to wild-type mice
increased epididymal fat pad weight ( J:80452 )
• the weight of the epididymal fat pad is increased compared to wild-type

growth/size/body
decreased susceptibility to diet-induced obesity ( J:80452 )
• on a high fat high calorie diet homozygotes do not gain as much weight as wild-type mice however, on a normal diet body weight is similar to wild-type

integument
decreased subcutaneous adipose tissue amount ( J:80452 )
• on a high fat high calorie diet the weight of the subcutaneous fat depot is reduced by 33% compared to wild-type




Genotype
MGI:3619036
hm2
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 24 hours of culture with low concentrations of anti-CD3 and anti-CD28 antibodies homozygous T cells produce less IL2
decreased T cell proliferation ( J:78190 )
• reduced proliferation of lymph node but not splenic T cells after stimulation with low concentrations of anti-CD3 antibody
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 24 hours of culture with low concentrations of anti-CD3 and anti-CD28 antibodies homozygous T cells produce less IL2
decreased T cell proliferation ( J:78190 )
• reduced proliferation of lymph node but not splenic T cells after stimulation with low concentrations of anti-CD3 antibody
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
decreased T cell proliferation ( J:78190 )
• reduced proliferation of lymph node but not splenic T cells after stimulation with low concentrations of anti-CD3 antibody
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells




Genotype
MGI:6450933
hm3
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:292691 )
N
• normal thickness, cell count and cell density of retina INL and GCL at age P30
• normal lamination of retina at age P7, P14 and P30
• normal cell counts for retinal ganglion, horizontal, bipolar, amacrine, and Mueller cells
increased retina cone cell number ( J:292691 )
• 2.7-fold increase in S-opsin- and 5-fold increase in M-opsin-positive cells at age P30
increased retina rod cell number ( J:292691 )
• 1.4-fold increase in rhodopsin-positive cells at age P30
abnormal retina outer nuclear layer morphology ( J:292691 )
• increased density and cell count at age P30
• normal thickness though trending towards slightly thicker at age P30
increased b-wave amplitude ( J:292691 )
• under photopic and scotopic conditions at age 1 month and 2 months

nervous system
increased retina cone cell number ( J:292691 )
• 2.7-fold increase in S-opsin- and 5-fold increase in M-opsin-positive cells at age P30
increased retina rod cell number ( J:292691 )
• 1.4-fold increase in rhodopsin-positive cells at age P30




Genotype
MGI:4948963
cn4
Allelic
Composition		 Krastm4Tyj/Kras+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (87 available)
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:170904 )
• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

respiratory system
increased lung tumor incidence ( J:170904 )
• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice




Genotype
MGI:3619044
cx5
Allelic
Composition		 Lepob/Lepob
Mapk8tm1Wag/Mapk8tm1Wag
Genetic
Background		 B6.Cg-Lepob Mapk8tm1Wag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (21 available)
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:80452 )
• decreased weight gain relative to Lepob single homozygotes

homeostasis/metabolism
decreased circulating glucose level ( J:80452 )
• decreased blood glucose level relative to Lepob single homozygotes
decreased circulating insulin level ( J:80452 )
• decreased blood insulin level relative to Lepob single homozygotes




Genotype
MGI:3619037
cx6
Allelic
Composition		 Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote




Genotype
MGI:3619038
cx7
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote




Genotype
MGI:3619039
cx8
Allelic
Composition		 Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

hematopoietic system
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
abnormal T cell activation ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote

cellular
decreased T cell apoptosis ( J:78190 )
• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
decreased T cell proliferation ( J:78190 )
• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote




Genotype
MGI:3619041
cx9
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:58622 )
• fewer than expected mice are found at weaning; however expected numbers are found at E12.5 to E15.5

nervous system
incomplete rostral neuropore closure ( J:58622 )
• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice
abnormal brain development ( J:58622 )
• at E15.5 in exencephalic mice, the brain tissue is expanded upward
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
absent brain ventricles ( J:58622 )
• at E12.5, in exencephalic mice the cerebral ventricles are absent
abnormal diencephalon morphology ( J:58622 )
• at E15.5 in exencephalic mice, the diencephalon is enlarged
abnormal cerebral hemisphere morphology ( J:58622 )
• at E15.5 in exencephalic mice, the cerebral hemispheres are displaced laterally
exencephaly ( J:58622 )
• some embryos display exencephaly with absence of the entire creanial roof at E12.5

embryo
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
incomplete rostral neuropore closure ( J:58622 )
• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice




Genotype
MGI:3619040
cx10
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
decreased hindbrain apoptosis ( J:58622 )
• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
increased forebrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
increased hindbrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
incomplete rostral neuropore closure ( J:58622 )
• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused
abnormal forebrain development ( J:58622 )
• the lumen of the forebrain vesicles is incompletely formed

growth/size/body
embryonic growth retardation ( J:58622 )

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:103476 )
• double homozygous MEFs display little or no CYP1A1 induction following TCDD treatment

embryo
abnormal embryonic neuroepithelial layer differentiation ( J:58622 )
• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
incomplete rostral neuropore closure ( J:58622 )
• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused

cellular
decreased hindbrain apoptosis ( J:58622 )
• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
increased forebrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
increased hindbrain apoptosis ( J:58622 )
• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells




Genotype
MGI:3619042
cx11
Allelic
Composition		 Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9tm1Mka
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:58622 )
N
• no mice display exencephaly and no indications of increased mortality are seen




Genotype
MGI:6384031
cx12
Allelic
Composition		 Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8tm1Wag
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
early eyelid opening ( J:176244 )
• eyes are open at birth
• however, mice exhibit normal retinal morphology




Genotype
MGI:6384032
cx13
Allelic
Composition		 Map3k1tm1Yxia/Map3k1+
Mapk8tm1Wag/Mapk8+
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation (0 available); any Map3k1 mutation (63 available)
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
early eyelid opening ( J:176244 )
• eyes are open at birth
• however, mice exhibit normal retinal morphology




Genotype
MGI:4948961
cx14
Allelic
Composition		 Mapk8tm1Wag/Mapk8tm1Wag
Mapk9tm1Mka/Mapk9+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation (1 available); any Mapk8 mutation (74 available)
Mapk9tm1Mka mutation (1 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eyelid morphology ( J:170904 )
• mice exhibit an eyelid closure defect compared with wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory