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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rorctm1Litt
targeted mutation 1, Dan R Littman
MGI:2384142
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rorctm1Litt/Rorctm1Litt involves: 129P2/OlaHsd MGI:3767257
cx2
 		Rorctm1Litt/Rorctm1Litt
Tcra-Jtm3.1Krg/Tcra-Jtm3.1Krg 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3767256


Genotype
MGI:3767257
hm1
Allelic
Composition		 Rorctm1Litt/Rorctm1Litt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorctm1Litt mutation (1 available); any Rorc mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )
• highly susceptible to C. rodentium and all die at day 10-12 post infection

cellular
abnormal cell cycle ( J:248565 )
• an increased number of thymocytes enter DNA synthesis (S phase) as compared to wild-type
increased thymocyte apoptosis ( J:248565 )
• decreased thymic cellularity due to accelerated apoptosis

endocrine/exocrine glands
increased thymocyte apoptosis ( J:248565 )
• decreased thymic cellularity due to accelerated apoptosis

hematopoietic system
increased thymocyte apoptosis ( J:248565 )
• decreased thymic cellularity due to accelerated apoptosis
abnormal T cell morphology ( J:248565 )
• thymocytes are enlarged
abnormal T cell differentiation ( J:128344 , J:248565 )
• primary rearrangement of 5' Jalpha segments is reduced to 54% and central Jalpha segments is reduced 18.2% (J:128344)
• cultured DN (CD4- CD8-) thymocytes do not differentiate into DP (CD4+ CD8+) thymocytes (J:248565)
• in vivo, DP thymocyte frequency and number is decreased, however, DN frequency and absolute number is similar to wild-type (J:248565)
abnormal CD8-positive, alpha-beta T cell differentiation ( J:248565 )
• CD8+ thymocytes remain immature CD24 TCR cells
abnormal T-helper 17 cell differentiation ( J:248565 )
• cultured CD4+ T cells are defective in TH17 differentiation under TH17 priming conditions
• T cells fail to differentiate in IL17-producing cells, however T cell can differentiate into TH1, TH2 and regulator T cells
decreased CD4-positive, alpha-beta T cell number ( J:248565 )
• frequency and number of CD4+ T cells is decreased as compared to wild-type

immune system
increased thymocyte apoptosis ( J:248565 )
• decreased thymic cellularity due to accelerated apoptosis
colitis ( J:158663 )
• inflammation, and edema post infection with C. rodentium
abnormal T cell morphology ( J:248565 )
• thymocytes are enlarged
abnormal T cell differentiation ( J:128344 , J:248565 )
• primary rearrangement of 5' Jalpha segments is reduced to 54% and central Jalpha segments is reduced 18.2% (J:128344)
• cultured DN (CD4- CD8-) thymocytes do not differentiate into DP (CD4+ CD8+) thymocytes (J:248565)
• in vivo, DP thymocyte frequency and number is decreased, however, DN frequency and absolute number is similar to wild-type (J:248565)
abnormal CD8-positive, alpha-beta T cell differentiation ( J:248565 )
• CD8+ thymocytes remain immature CD24 TCR cells
abnormal T-helper 17 cell differentiation ( J:248565 )
• cultured CD4+ T cells are defective in TH17 differentiation under TH17 priming conditions
• T cells fail to differentiate in IL17-producing cells, however T cell can differentiate into TH1, TH2 and regulator T cells
decreased CD4-positive, alpha-beta T cell number ( J:248565 )
• frequency and number of CD4+ T cells is decreased as compared to wild-type
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:248565 )
• EAE development is attenuated in females immunized with EAE-inducing MOG epitope
increased susceptibility to bacterial infection ( J:158663 )
• display weight loss, colitis and severe disruption of the epithelial layer in the colon after infection with Citrobacter rodentium
increased susceptibility to bacterial infection induced morbidity/mortality ( J:158663 )
• highly susceptible to C. rodentium and all die at day 10-12 post infection

growth/size/body
weight loss ( J:158663 )
• exhibit weight loss post infection with C. rodentium

digestive/alimentary system
abnormal colon morphology ( J:158663 )
• severe disruption of the epithelial layer post infection with C. rodentium
colonic necrosis ( J:158663 )
• multifocal necrosis in colon post infection with C. rodentium
colitis ( J:158663 )
• inflammation, and edema post infection with C. rodentium




Genotype
MGI:3767256
cx2
Allelic
Composition		 Rorctm1Litt/Rorctm1Litt
Tcra-Jtm3.1Krg/Tcra-Jtm3.1Krg
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorctm1Litt mutation (1 available); any Rorc mutation (44 available)
Tcra-Jtm3.1Krg mutation (0 available); any Tcra-J mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:128344 )
• unlike in Rorctm1Litt homozygotes, primary rearrangement of 5' Jalpha segments is completely abolished (0.5% compared to 54% in Rorctm1Litt homozygotes) while rearrangement of the central Jalpha segments is increased (54.8% compared to 18.2% in Rorctm1Litt homozygotes)

immune system
abnormal T cell differentiation ( J:128344 )
• unlike in Rorctm1Litt homozygotes, primary rearrangement of 5' Jalpha segments is completely abolished (0.5% compared to 54% in Rorctm1Litt homozygotes) while rearrangement of the central Jalpha segments is increased (54.8% compared to 18.2% in Rorctm1Litt homozygotes)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory