All Phenotypes Cdkn2a<tm2Brn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdkn2a^tm2Brn
targeted mutation 2, Anton Berns
MGI:2384163

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Nf2^tm2Gth/Nf2⁺	involves: 129P2/OlaHsd	MGI:3850444
cn2	Cdkn2a^tm2Brn/Cdkn2a⁺ Nf2^tm2Gth/Nf2^tm2Gth	involves: 129P2/OlaHsd	MGI:3850445
cn3	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Nf2^tm2Gth/Nf2^tm2Gth	involves: 129P2/OlaHsd	MGI:3850440
cn4	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Ezh1^tm1Sgon/Ezh1^tm1Sgon Tg(VAV1-cre)1Graf/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5474784
cn5	Atr^tm2Bal/Atr^tm2Bal Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL	MGI:5316228
cn6	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0	involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N	MGI:5484548
cn7	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0	involves: C57BL/6 * FVB/N	MGI:5603215

Allelic Composition	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Nf2^tm2Gth/Nf2⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2Brn mutation (2 available); any Cdkn2a mutation (67 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:132943 )

• following adenoviral cre treatment, median survival time is 410 days

neoplasm

increased tumor incidence ( J:132943 )

• following adenoviral cre treatment, 34% of mice develop thoracic tumors (including malignant mesotheliomas, 14 of 41) with a longer latency than in mice homozygous for all alleles

• following adenoviral cre treatment, 24% of mice develop aspecific tumors not induced by adeno-cre treatment

increased uterus leiomyoma incidence ( J:132943 )

• in 17% of mice following adenoviral cre treatment

increased leukemia incidence ( J:132943 )

• following adenoviral cre treatment, 54% of mice develop monocytic myeloid leukemias

muscle

increased uterus leiomyoma incidence ( J:132943 )

• in 17% of mice following adenoviral cre treatment

reproductive system

increased uterus leiomyoma incidence ( J:132943 )

• in 17% of mice following adenoviral cre treatment

Allelic Composition	Cdkn2a^tm2Brn/Cdkn2a⁺ Nf2^tm2Gth/Nf2^tm2Gth
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:132943 )

• following adenoviral cre treatment, median survival time is 495 days

neoplasm

increased tumor incidence ( J:132943 )

• following adenoviral cre treatment, 35% of mice develop thoracic tumors (including malignant mesotheliomas, 18 of 52) with a longer latency than in mice homozygous for all alleles

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

• following adenoviral cre treatment, 19% of mice develop aspecific tumors not induced by adeno-cre treatment

increased uterus leiomyoma incidence ( J:132943 )

• in 16% of mice following adenoviral cre treatment

increased leukemia incidence ( J:132943 )

• following adenoviral cre treatment, 16% of mice develop monocytic myeloid leukemias

liver/biliary system

enlarged liver ( J:132943 )

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

muscle

increased uterus leiomyoma incidence ( J:132943 )

• in 16% of mice following adenoviral cre treatment

growth/size/body

enlarged liver ( J:132943 )

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

reproductive system

increased uterus leiomyoma incidence ( J:132943 )

• in 16% of mice following adenoviral cre treatment

Allelic Composition	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Nf2^tm2Gth/Nf2^tm2Gth
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:132943 )

• following adenoviral cre treatment, median survival time is 220 days

neoplasm

increased tumor incidence ( J:132943 )

• following adenoviral cre treatment, 83% of mice develop highly invasive thoracic tumors (including malignant mesotheliomas, 45 of 57; rhabdomyosarcomas, 3 of 57; and schwannomas, 1 of 57)

• following adenoviral cre treatment, mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

• following adenoviral cre treatment, 4% of mice develop aspecific tumors not induced by adeno-cre treatment

• following adenoviral cre treatment, 70% of mice develop aggressive malignant mesotheliomas, which is higher than in mice carrying other combinations of Cdkn2a^tm2Brn, Nf2^tm2Gth, and Trp53^tm1Brn alleles

increased uterus leiomyoma incidence ( J:132943 )

• in 4% of mice following adenoviral cre treatment

increased rhabdomyosarcoma incidence ( J:132943 )

increased leukemia incidence ( J:132943 )

• following adenoviral cre treatment, 7% mice develop monocytic myeloid leukemias

liver/biliary system

enlarged liver ( J:132943 )

• following adenoviral cre treatment, 42% of mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

reproductive system

increased uterus leiomyoma incidence ( J:132943 )

• in 4% of mice following adenoviral cre treatment

muscle

increased uterus leiomyoma incidence ( J:132943 )

• in 4% of mice following adenoviral cre treatment

increased rhabdomyosarcoma incidence ( J:132943 )

growth/size/body

enlarged liver ( J:132943 )

• following adenoviral cre treatment, 42% of mice develop hepatomegaly either due to oval cell hyperplasia, cholangio-carcinomas and/or hepatomas, and leiomyomas of the uterus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant mesothelioma		DOID:1790	OMIM:156240	J:132943

Allelic Composition	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Ezh1^tm1Sgon/Ezh1^tm1Sgon Tg(VAV1-cre)1Graf/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2Brn mutation (2 available); any Cdkn2a mutation (67 available)
Ezh1^tm1Sgon mutation (0 available); any Ezh1 mutation (34 available)
Tg(VAV1-cre)1Graf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:193722 )

N	• rescue of hematopoiesis by increasing proliferation and alleviating senescence

Allelic Composition	Atr^tm2Bal/Atr^tm2Bal Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atr^tm2Bal mutation (1 available); any Atr mutation (133 available)
Cdkn2a^tm2Brn mutation (2 available); any Cdkn2a mutation (67 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system morphology ( J:181920 )

• similar neuropathology to mutant mice wild-type for Cdkn2a

Allelic Composition	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2Brn mutation (2 available); any Cdkn2a mutation (67 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas development ( J:195229 )

• after 5 days in culture, pancreatic explants exhibit irregular branching and disorganization with increased proliferation, pseudostratification, nuclear crowding and elongation resembling precancerous lesions

• however, no cysts develop

cellular

increased cell proliferation ( J:195229 )

• after 5 days in culture, pancreatic explants exhibit irregular branching with increased proliferation

Allelic Composition	Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2Brn mutation (2 available); any Cdkn2a mutation (67 available)
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased classified tumor incidence ( J:107175 )

• following OHT treatment melanomas are detected in 33% of mice (11 of 33, with 7 pigmented and 4 nonpigmented)

• tumors are often multiple and appear on hairy skin

increased cutaneous melanoma incidence ( J:107175 )

• average pigmented tumor latency is 73 days and mice survive for an average period of 161 days from time of first lesion observation until death

• tumors display the pathologic features of cutaneous spindle-cell melanoma and consist of spindle-shaped melanoma cells and numerous large macrophages loaded with melanin

• tumors are locally invasive with tumor cells found in the lymph nodes

increased neurofibrosarcoma incidence ( J:107175 )

integument

increased cutaneous melanoma incidence ( J:107175 )

• average pigmented tumor latency is 73 days and mice survive for an average period of 161 days from time of first lesion observation until death

• tumors display the pathologic features of cutaneous spindle-cell melanoma and consist of spindle-shaped melanoma cells and numerous large macrophages loaded with melanin

• tumors are locally invasive with tumor cells found in the lymph nodes

nervous system

increased neurofibrosarcoma incidence ( J:107175 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:107175

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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