Phenotypes associated with this allele

• Allele Symbol: Cdkn2a^tm2.1Brn
• Allele Name: targeted mutation 2.1, Anton Berns
• Allele ID: MGI:2384164
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn	involves: 129P2/OlaHsd * FVB/N	MGI:3766093
cx2	Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn Hdac2^tm1.2Rdp/Hdac2^tm1.2Rdp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5494635

Genotype
MGI:3766093

hm1

• Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:71393 )

• in 3 of 8 melanocytic tumors (2 dimethylbenzantrene-induced and 1 spontaneous), metastases is observed in the lymph nodes, lungs, spleen or liver whereas dimethylbenzantrene-treated wild-type mice do not develop melanomas

increased tumor incidence ( J:71393 )

• by 17 months all mice develop sarcomas, carcinomas, lymphomas and metastatic melanomas with an average latency of 12 months whereas only 25% of wild-type mice develop tumors within the same time frame

increased incidence of tumors by chemical induction ( J:71393 )

• mice treated with dimethylbenzantrene (DMBA) develop skin papillomas and pulmonary adenocarcinomas

• 7 of 14 mice treated with DMBA develop cutaneous melanocytic tumors between 3 and 9 months of age

increased lymphoma incidence ( J:71393 )

increased carcinoma incidence ( J:71393 )

increased melanoma incidence ( J:71393 )

increased sarcoma incidence ( J:71393 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:71393 )

• mice treated with dimethylbenzantrene (DMBA) develop skin papillomas and pulmonary adenocarcinomas

• 7 of 14 mice treated with DMBA develop cutaneous melanocytic tumors between 3 and 9 months of age

Genotype
MGI:5494635

cx2

• Allelic Composition: Cdkn2a^tm2.1Brn/Cdkn2a^tm2.1Brn; Hdac2^tm1.2Rdp/Hdac2^tm1.2Rdp
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

cellular

abnormal mitosis ( J:197818 )

• cell cycle arrest in mouse embryonic fibroblasts treated with Hdac1 shRNA