All Phenotypes Cdkn2a<tm2.1Rdp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdkn2a^tm2.1Rdp
targeted mutation 2.1, Ronald DePinho
MGI:2384177

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp	involves: 129S6/SvEvTac * FVB/N	MGI:3814389
ht2	Cdkn2a^tm2.1Rdp/Cdkn2a⁺	involves: 129S6/SvEvTac * FVB/N	MGI:3814390
cn3	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53⁺ Tg(Pdx1-cre)89.1Dam/0	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5308962
cn4	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Pdx1-cre)89.1Dam/0	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5308954
cn5	Cdkn2a^tm2.1Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53⁺ Tg(Pdx1-cre)89.1Dam/0	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5308961
cn6	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)89.1Dam/0	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5308963
cn7	Cdkn2a^tm2.1Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Pdx1-cre)89.1Dam/0	involves: 129 * C57BL/6 * CBA * FVB/N	MGI:5308951
cn8	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5659885
cn9	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5659896
cn10	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N	MGI:5502381
cx11	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Nf1^tm1Tyj/Nf1⁺	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:3776068
cx12	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Tg(GFAP-TVA)5Hev/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N	MGI:3835352
cx13	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Tg(NES-TVA)J12Ech/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:3835366
cx14	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp X/Tg(Tyr-HRAS)60Lc	involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB	MGI:2676124

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:71394 , J:88365 )

• between 28 and 58 weeks, 10 out of 39 mice develop tumors unlike wild-type mice (J:71394)

• increase in spontaneous and carcinogen-induced tumor incidence, but less than in Cdkn2a^tm1Rdp mice (J:88365)

• 12% and 5% of spontaneous and DMBA-induced tumors, respectively, that form in mutants are melanomas (J:88365)

increased incidence of tumors by chemical induction ( J:71394 , J:88365 )

• following treatment with DMBA, 50% of mice develop tumors by week 23 compared to later than week 35 for similarly treated wild-type mice (J:71394)

• following treatment with DMBA, mice develop lung adenomas that are more aggressive than in similarly treated wild-type mice (J:71394)

• following treatment with DMBA, mice exhibit an increase in spindle-cell neoplasms compared to in similarly treated wild-type mice (J:71394)

• treatment of mice with urethane results in a 4-fold increase in the number of lung adenomas compared to in similarly treated wild-type mice (J:71394)

increased lymphoma incidence ( J:88365 )

• 18% of spontaneous tumors that form in mutants are histiocytic lymphomas

increased small lymphocytic lymphoma incidence ( J:88365 )

• spontaneous lymphocytic lymphomas are not observed in mutants, however 40% of DMBA-induced tumors are small lymphocytic lymphomas

increased sarcoma incidence ( J:88365 )

• 29% of spontaneous tumors that form in mutants are malignant spindle cell neoplasms, most likely soft tissue sarcomas

• 23% of spontaneous tumors that form are angiosarcomas

• 30% of DMBA-induced tumors are malignant spindle cell neoplasms

increased osteosarcoma incidence ( J:88365 )

• 18% of spontaneous tumors that form in mutants are osteosarcomas

immune system

increased splenocyte proliferation ( J:71394 )

• unsorted splenocytes exhibit increased proliferation compared to wild-type cells when stimulated with CD3 and CD28 but not LPS or IgM with CD40

increased thymus weight ( J:71394 )

thymus hyperplasia ( J:71394 )

• the thymus exhibits increased cortical thickness and cellularity

increased double-positive T cell number ( J:71394 )

• mice exhibit a marked increased in the double positive compartment

increased CD4-positive, alpha-beta T cell number ( J:71394 )

increased CD8-positive, alpha-beta T cell number ( J:71394 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:71394 , J:88365 )

• following treatment with DMBA, 50% of mice develop tumors by week 23 compared to later than week 35 for similarly treated wild-type mice (J:71394)

• following treatment with DMBA, mice develop lung adenomas that are more aggressive than in similarly treated wild-type mice (J:71394)

• following treatment with DMBA, mice exhibit an increase in spindle-cell neoplasms compared to in similarly treated wild-type mice (J:71394)

• treatment of mice with urethane results in a 4-fold increase in the number of lung adenomas compared to in similarly treated wild-type mice (J:71394)

hematopoietic system

increased splenocyte proliferation ( J:71394 )

• unsorted splenocytes exhibit increased proliferation compared to wild-type cells when stimulated with CD3 and CD28 but not LPS or IgM with CD40

increased thymus weight ( J:71394 )

thymus hyperplasia ( J:71394 )

• the thymus exhibits increased cortical thickness and cellularity

increased double-positive T cell number ( J:71394 )

• mice exhibit a marked increased in the double positive compartment

increased CD4-positive, alpha-beta T cell number ( J:71394 )

increased CD8-positive, alpha-beta T cell number ( J:71394 )

cellular

increased splenocyte proliferation ( J:71394 )

• unsorted splenocytes exhibit increased proliferation compared to wild-type cells when stimulated with CD3 and CD28 but not LPS or IgM with CD40

endocrine/exocrine glands

increased thymus weight ( J:71394 )

thymus hyperplasia ( J:71394 )

• the thymus exhibits increased cortical thickness and cellularity

skeleton

increased osteosarcoma incidence ( J:88365 )

• 18% of spontaneous tumors that form in mutants are osteosarcomas

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a⁺
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:71394 )

• between 28 and 58 weeks, 4 out of 60 mice develop tumors unlike wild-type mice

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53⁺ Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 13.1 weeks

• 25% of tumors exhibit sarcomatoid carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 75% of tumors exhibit well differentiated ductal adenocarcinoma histology

increased metastatic potential ( J:108298 )

• 25% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 13.1 weeks

• 25% of tumors exhibit sarcomatoid carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 75% of tumors exhibit well differentiated ductal adenocarcinoma histology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:108298

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 7.2 weeks

• 60% of tumors exhibit anaplastic carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 40% of tumors exhibit well differentiated ductal adenocarcinoma histology

increased metastatic potential ( J:108298 )

• 20% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 7.2 weeks

• 60% of tumors exhibit anaplastic carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 40% of tumors exhibit well differentiated ductal adenocarcinoma histology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:108298

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53⁺ Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 14.7 weeks

• 19% of tumors exhibit sarcomatoid differentiation

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 81% of tumors exhibit well differentiated ductal adenocarcinoma histology

increased metastatic potential ( J:108298 )

• 25% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 14.7 weeks

• 19% of tumors exhibit sarcomatoid differentiation

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 81% of tumors exhibit well differentiated ductal adenocarcinoma histology

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 18.3 weeks

• 100% of tumors are sarcomatoid in histology

increased metastatic potential ( J:108298 )

• 33% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 18.3 weeks

• 100% of tumors are sarcomatoid in histology

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a⁺ Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 6.5 weeks

• 20% of tumors exhibit anaplastic carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 80% of tumors exhibit well differentiated ductal adenocarcinoma histology

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 6.5 weeks

• 20% of tumors exhibit anaplastic carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 80% of tumors exhibit well differentiated ductal adenocarcinoma histology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:108298

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:124682 )

• mice inoculated with an adenovirus expressing cre recombinase (ad-cre) by inhalation have a median survival of 29 weeks after ad-cre inoculation

cardiovascular system

lung hemorrhage ( J:124682 )

• mice inoculated with ad-cre exhibit a high frequency of fatal pulmonary hemorrhage

respiratory system

lung hemorrhage ( J:124682 )

• mice inoculated with ad-cre exhibit a high frequency of fatal pulmonary hemorrhage

increased lung tumor incidence ( J:124682 )

• some ad-cre inoculated mice develop lung tumors with low tumor multiplicity

neoplasm

increased lung tumor incidence ( J:124682 )

• some ad-cre inoculated mice develop lung tumors with low tumor multiplicity

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:124682 )

• mice inoculated with an adenovirus expressing cre recombinase (ad-cre) by inhalation have a median survival of 24 weeks after ad-cre inoculation

neoplasm

increased metastatic potential ( J:124682 )

• 3 of 15 (20%) ad-cre inoculated mice exhibit metastasis

increased lung adenocarcinoma incidence ( J:124682 )

• mice inoculated with ad-cre by inhalation develop infrequent highly lethal tumors; all tumors are adenocarcinomas

respiratory system

increased lung adenocarcinoma incidence ( J:124682 )

• mice inoculated with ad-cre by inhalation develop infrequent highly lethal tumors; all tumors are adenocarcinomas

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:198619 )

• median survival 15.5 weeks

neoplasm

increased pancreas tumor incidence ( J:198619 )

• starting between 6 and 24 weeks with metastasis

increased pancreas adenoma incidence ( J:198619 )

• adenocarcinomas in 21 of 22 invasive carcinomas in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:198619 )

increased adenocarcinoma incidence ( J:198619 )

• adenocarcinomas in 21 of 22 invasive carcinomas in the pancreas

growth/size/body

weight loss ( J:198619 )

• starting between 6 and 24 weeks

distended abdomen ( J:198619 )

• increased girth starting between 6 and 24 weeks

liver/biliary system

jaundice ( J:198619 )

• starting between 6 and 24 weeks

homeostasis/metabolism

ascites ( J:198619 )

• starting between 6 and 24 weeks

endocrine/exocrine glands

increased pancreas tumor incidence ( J:198619 )

• starting between 6 and 24 weeks with metastasis

increased pancreas adenoma incidence ( J:198619 )

• adenocarcinomas in 21 of 22 invasive carcinomas in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:198619 )

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Nf1^tm1Tyj/Nf1⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Nf1^tm1Tyj mutation (3 available); any Nf1 mutation (161 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:131914 )

N	• unlike other mice with at least one Nf1^tm1Tyj allele, mice do not display malignant peripheral nerve sheath tumors or neurofibromas

increased lymphoma incidence ( J:131914 )

• hematopoietic neoplasms, especially lymphoma, are seen in some mice

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Tg(GFAP-TVA)5Hev/0
Genetic Background	involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm

increased glioma incidence ( J:125535 )

• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)

nervous system

increased glioma incidence ( J:125535 )

• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Tg(NES-TVA)J12Ech/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Tg(NES-TVA)J12Ech mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 20% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice

neoplasm

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 21 grade II (similar to human oligodendroglioma) and 1 grade III (similar to anaplastic oligodendroglioma)

nervous system

increased glioma incidence ( J:125535 )

• 22 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 21 grade II (similar to human oligodendroglioma) and 1 grade III (similar to anaplastic oligodendroglioma)

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp X/Tg(Tyr-HRAS)60Lc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Tg(Tyr-HRAS)60Lc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:85075 )

• 75 week melanoma free survival as opposed to 89 weeks for wild-type mice

• functioning of p19^ARF was compromised in more than half of the tumors examined

• about 40% of tumors overexpressed p53 as demonstrated by Western blot analysis

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