immune system
• thymus cellularity is only 10-30% of controls
|
• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs
• these DN3 cells have less proliferation suggesting a partial block in development
|
• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal
|
• single-positive thymocyte numbers are decreased compared to controls
|
hematopoietic system
• thymus cellularity is only 10-30% of controls
|
• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs
• these DN3 cells have less proliferation suggesting a partial block in development
|
• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal
|
• single-positive thymocyte numbers are decreased compared to controls
|
endocrine/exocrine glands
• thymus cellularity is only 10-30% of controls
|