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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shc1tm1Ravi
targeted mutation 1, Kodi S Ravichandran
MGI:2384183
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Shc1tm1Ravi/Shc1tm1Ravi
Tg(Lck-cre)1Cwi/? 		involves: 129 * C57BL/6 MGI:3851535
cn2
 		Shc1tm1Ravi/Shc1tm1Ravi
Tg(Nes-cre)1Kln/0 		involves: 129 * C57BL/6 * SJL MGI:3851590


Genotype
MGI:3851535
cn1
Allelic
Composition		 Shc1tm1Ravi/Shc1tm1Ravi
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm1Ravi mutation (1 available); any Shc1 mutation (66 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:78180 )
• thymus cellularity is only 10-30% of controls
abnormal double-negative T cell morphology ( J:78180 )
• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs
• these DN3 cells have less proliferation suggesting a partial block in development
decreased double-positive T cell number ( J:78180 )
• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal
decreased single-positive T cell number ( J:78180 )
• single-positive thymocyte numbers are decreased compared to controls

hematopoietic system
thymus hypoplasia ( J:78180 )
• thymus cellularity is only 10-30% of controls
abnormal double-negative T cell morphology ( J:78180 )
• double-negative thymocyte numbers are similar to wild-type but the distribution of the sub-populations differs
• these DN3 cells have less proliferation suggesting a partial block in development
decreased double-positive T cell number ( J:78180 )
• double-positive thymocyte numbers are decreased compared to wild-type while double-negative numbers are close to normal
decreased single-positive T cell number ( J:78180 )
• single-positive thymocyte numbers are decreased compared to controls

endocrine/exocrine glands
thymus hypoplasia ( J:78180 )
• thymus cellularity is only 10-30% of controls




Genotype
MGI:3851590
cn2
Allelic
Composition		 Shc1tm1Ravi/Shc1tm1Ravi
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm1Ravi mutation (1 available); any Shc1 mutation (66 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:111058 )
• body weight is less than controls at 25 days of age

nervous system
decreased brain size ( J:111058 )
• brain weight is less than controls at 25 days of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory