About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppargtm1Gonz
targeted mutation 1, Frank J Gonzales
MGI:2384211
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppargtm1Gonz/Ppargtm1Gonz
Tg(Wap-cre)11738Mam/? 		involves: 129X1/SvJ * C57BL/6 * SJL MGI:3722296
cn2
 		Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)1Mam/? 		involves: 129X1/SvJ * FVB MGI:3722293
cn3
 		Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)4Mam/? 		involves: 129X1/SvJ * FVB MGI:3722294


Genotype
MGI:3722296
cn1
Allelic
Composition		 Ppargtm1Gonz/Ppargtm1Gonz
Tg(Wap-cre)11738Mam/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (41 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:76553 )
N
• mice have normal mammary gland development




Genotype
MGI:3722293
cn2
Allelic
Composition		 Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)1Mam/?
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (41 available)
Tg(MMTV-cre)1Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal mammary gland growth during pregnancy ( J:76553 )
• alveolar development induced by pregnancy is impaired
• females cannot nurse pups
female infertility ( J:76553 )
• one third of females are infertile
reduced female fertility ( J:76553 )
• females that can bred have reduced fertility
decreased litter size ( J:76553 )
• females that can bred produce smaller litters

endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:76553 )
• alveolar development induced by pregnancy is impaired
• females cannot nurse pups

integument
abnormal mammary gland growth during pregnancy ( J:76553 )
• alveolar development induced by pregnancy is impaired
• females cannot nurse pups




Genotype
MGI:3722294
cn3
Allelic
Composition		 Ppargtm1Gonz/Ppargtm1Gonz
Tg(MMTV-cre)4Mam/?
Genetic
Background		 involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1Gonz mutation (0 available); any Pparg mutation (41 available)
Tg(MMTV-cre)4Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:76553 )
N
• mice have normal mammary gland development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory