Analysis Tools|
Allele Symbol Allele Name Allele ID |
Irak1tm1Jth targeted mutation 1, James A Thomas MGI:2384212 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• almost completely resistant to experimental autoimmune encephalomyelitis induced by injection of myelin oligodendrocyte glycoprotein
• T cells failed to respond to antigen early but response after about 1 month was normal as was Ifn-gamma production
• reduced macrophage infiltration into central nervous system
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type
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• cytokine production in response to TLR ligands such as LPS or CpG DNA is defective
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• after challenge with LPS or CpG DNA together with D-galactosamine, no mutants died in contrast to 100% mortality of wild-type to endotoxic shock
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• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• mice survived past 150 days of age
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• only in about 10% of mice, otherwise normal
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• cardiac myocytes undergoing degenerative changes
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• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts
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• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts
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• cardiac myocytes undergoing degenerative changes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
N |
• mice survived past 150 days of age
|
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• only in about 10% of mice, otherwise normal
|
|
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• cardiac myocytes undergoing degenerative changes
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• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts
|
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• diffuse interstitial cellularity
• mononuclear inflammatory cells and fibroblasts
|
|
|
• cardiac myocytes undergoing degenerative changes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• almost completely resistant to experimental autoimmune encephalomyelitis induced by injection of myelin oligodendrocyte glycoprotein
• T cells failed to respond to antigen early but response after about 1 month was normal as was Ifn-gamma production
• reduced macrophage infiltration into central nervous system
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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