Phenotypes associated with this allele

• Allele Symbol: Mlh3^tm1Lpkn
• Allele Name: targeted mutation 1, Steven M Lipkin
• Allele ID: MGI:2384218
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlh3^tm1Lpkn/Mlh3^tm1Lpkn	involves: 129S/SvEv	MGI:2663891

Genotype
MGI:2663891

hm1

• Allelic Composition: Mlh3^tm1Lpkn/Mlh3^tm1Lpkn
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

small testis ( J:78200 )

♂

abnormal gametogenesis ( J:78200 )

• germ cell apoptosis following meiotic defects

azoospermia ( J:78200 )

♂

abnormal female meiosis ( J:78200 )

♀ • 7% of oocytes progressed to the 2 cell stage

abnormal male meiosis ( J:78200 )

♂ • some spermatocytes arrest at pachytene

♂ • most spermatocytes progressed to metaphase at which point they showed missegregation and aneuploidy

female infertility ( J:78200 )

♀

male infertility ( J:78200 )

♂

endocrine/exocrine glands

small testis ( J:78200 )

♂

cellular

azoospermia ( J:78200 )

♂

abnormal female meiosis ( J:78200 )

♀ • 7% of oocytes progressed to the 2 cell stage

abnormal male meiosis ( J:78200 )

♂ • some spermatocytes arrest at pachytene

♂ • most spermatocytes progressed to metaphase at which point they showed missegregation and aneuploidy