Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm1Lfr
• Allele Name: targeted mutation 1, Louis F Reichardt
• Allele ID: MGI:2384391
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk2^tm1Lfr/Ntrk2^tm1Lfr	involves: 129X1/SvJ	MGI:3717376
ht2	Ntrk2^tm1Lfr/Ntrk2^+	involves: 129X1/SvJ	MGI:3717377
cn3	Ntrk2^tm1Lfr/Ntrk2^tm1Lfr Tg(Camk2a-cre)1Lfr/0	involves: 129X1/SvJ * C57BL/6 * DBA	MGI:2450114

Genotype
MGI:3717376

hm1

• Allelic Composition: Ntrk2^tm1Lfr/Ntrk2^tm1Lfr
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:119332 , J:122929 )

• by P90, the number of retinal ganglion cell axons is reduced by 16% with the greatest effect on myelinated axons (J:119332)

• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in Ntrk2^tm1Lfr heterozygotes and wild-type mice (J:122929)

• at P28, mice have a greater percent of ON-OFF RGCs than wild-type at P13 (J:122929)

• at P28, mice have fewer ON RGCs than wild-type mice (J:122929)

decreased retina ganglion cell number ( J:119332 )

• cells in the retinal ganglion layer are reduced by 20% at 3 months of age

nervous system

abnormal retina ganglion cell morphology ( J:119332 , J:122929 )

• by P90, the number of retinal ganglion cell axons is reduced by 16% with the greatest effect on myelinated axons (J:119332)

• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in Ntrk2^tm1Lfr heterozygotes and wild-type mice (J:122929)

• at P28, mice have a greater percent of ON-OFF RGCs than wild-type at P13 (J:122929)

• at P28, mice have fewer ON RGCs than wild-type mice (J:122929)

decreased retina ganglion cell number ( J:119332 )

• cells in the retinal ganglion layer are reduced by 20% at 3 months of age

Genotype
MGI:3717377

ht2

• Allelic Composition: Ntrk2^tm1Lfr/Ntrk2⁺
• Genetic Background: involves: 129X1/SvJ

vision/eye

abnormal retina ganglion cell morphology ( J:122929 )

• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in wild-type mice but fewer than in Ntrk2^tm1Lfr heterozygotes

nervous system

abnormal retina ganglion cell morphology ( J:122929 )

• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in wild-type mice but fewer than in Ntrk2^tm1Lfr heterozygotes

Genotype
MGI:2450114

cn3

• Allelic Composition: Ntrk2^tm1Lfr/Ntrk2^tm1Lfr; Tg(Camk2a-cre)1Lfr/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

nervous system

abnormal somatosensory cortex morphology ( J:77452 )

• compression occurs

abnormal visual cortex morphology ( J:77452 )

• severe compression of layers II/III and layer V of the visual cortex

abnormal neuron morphology ( J:77452 )

• mice exhibit a loss of Pou3f1-expressing neurons

• neuron cell bodies exhibit a 27% reduction in size with round morphology

abnormal dendrite morphology ( J:77452 )

• dendrites are thin and exhibit reduced complexity

• primary dendrites possess fewer and/or shorter branches

• the average apical diameter of a dendrite is reduced by 41% compared to in heterozygotes

decreased neuron number ( J:77452 )

• mice exhibit a loss of Pou3f1-expressing neurons