Phenotypes associated with this allele

• Allele Symbol: Nfatc1^tm2Glm
• Allele Name: targeted mutation 2, Laurie H Glimcher
• Allele ID: MGI:2384395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nfatc1^tm1Glm/Nfatc1^tm2Glm	chimera involves: 129S2/SvPas	MGI:3844068

Genotype
MGI:3844068

ht1

• Allelic Composition: Nfatc1^tm1Glm/Nfatc1^tm2Glm
• Genetic Background: chimera involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphocyte cell number ( J:78376 )

increased double-negative T cell number ( J:78376 )

• in all hypoplastic thymi but are blastocyst derived

decreased lymphocyte cell number ( J:78376 )

• marked deficiency of thymocytes, peripheral lymph node cells, and splenic lymphocytes in four of seven 10-22 week old chimeric mice

• inverse relationsip between the degree of chimerism and lymphoid reconsititution in five mice between 10 and 14 weeks in age

• mice at 17 and 22 weeks show normal lymphoid reconstitution

• ratio of T to B cells normal

decreased double-positive T cell number ( J:78376 )

• decreased numbers but normal ratio of CD4+ to CD8+ single positive cells

abnormal immune system physiology ( J:78376 )

abnormal lymphocyte physiology ( J:78376 )

abnormal B cell physiology ( J:78376 )

• diminished proliferative response to anti-CD40

• response to anti-CD40 in culture can be partially restored by recombinant Il4

abnormal immunoglobulin level ( J:78376 )

decreased immunoglobulin level ( J:78376 )

decreased IgE level ( J:78376 )

• markedly decreased

• corrollated to Il4 levels secreted by T-cells

decreased IgG1 level ( J:78376 )

• markedly decreased

• corrollated to Il4 levels secreted by T-cells

decreased IgG2b level ( J:78376 )

• normal to slightly decreased

decreased IgG3 level ( J:78376 )

• normal to slightly decreased

increased immunoglobulin level ( J:78376 )

increased IgA level ( J:78376 )

increased IgG2a level ( J:78376 )

increased IgM level ( J:78376 )

abnormal T cell physiology ( J:78376 )

• reduced proliferative response to anti-CD3

abnormal T-helper 2 physiology ( J:78376 )

• impaired generation of Th2 cells

abnormal interferon-gamma secretion ( J:78376 )

abnormal interleukin-2 secretion ( J:78376 )

decreased interleukin-4 secretion ( J:78376 )

• very reduced

hematopoietic system

abnormal lymphocyte cell number ( J:78376 )

increased double-negative T cell number ( J:78376 )

• in all hypoplastic thymi but are blastocyst derived

decreased lymphocyte cell number ( J:78376 )

• marked deficiency of thymocytes, peripheral lymph node cells, and splenic lymphocytes in four of seven 10-22 week old chimeric mice

• inverse relationsip between the degree of chimerism and lymphoid reconsititution in five mice between 10 and 14 weeks in age

• mice at 17 and 22 weeks show normal lymphoid reconstitution

• ratio of T to B cells normal

decreased double-positive T cell number ( J:78376 )

• decreased numbers but normal ratio of CD4+ to CD8+ single positive cells

abnormal lymphocyte physiology ( J:78376 )

abnormal B cell physiology ( J:78376 )

• diminished proliferative response to anti-CD40

• response to anti-CD40 in culture can be partially restored by recombinant Il4

abnormal immunoglobulin level ( J:78376 )

decreased immunoglobulin level ( J:78376 )

decreased IgE level ( J:78376 )

• markedly decreased

• corrollated to Il4 levels secreted by T-cells

decreased IgG1 level ( J:78376 )

• markedly decreased

• corrollated to Il4 levels secreted by T-cells

decreased IgG2b level ( J:78376 )

• normal to slightly decreased

decreased IgG3 level ( J:78376 )

• normal to slightly decreased

increased immunoglobulin level ( J:78376 )

increased IgA level ( J:78376 )

increased IgG2a level ( J:78376 )

increased IgM level ( J:78376 )

abnormal T cell physiology ( J:78376 )

• reduced proliferative response to anti-CD3

abnormal T-helper 2 physiology ( J:78376 )

• impaired generation of Th2 cells