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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gasttm1Psi
targeted mutation 1, Pomila Singh
MGI:2384400
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gasttm1Psi/Gasttm1Psi involves: C57BL/6J MGI:2672024


Genotype
MGI:2672024
hm1
Allelic
Composition
Gasttm1Psi/Gasttm1Psi
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gasttm1Psi mutation (0 available); any Gast mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• increase in susceptibility to colon cancers in response to azoxymethane (AOM), developing higher total numbers of tumors and at earlier times than in controls
• mutant females develop adenomas and adenocarcinomas earlier than mutant males and wild-type mice

digestive/alimentary system
• colonic proliferation in response to azoxymethane (AOM) is increased compared to wild-type
• aberrant crypt foci are increased by about 2-5-fold after 2 weeks of AOM treatment compared to wild-type mice

homeostasis/metabolism
• colonic proliferation in response to azoxymethane (AOM) is increased compared to wild-type
• aberrant crypt foci are increased by about 2-5-fold after 2 weeks of AOM treatment compared to wild-type mice
• increase in susceptibility to colon cancers in response to azoxymethane (AOM), developing higher total numbers of tumors and at earlier times than in controls
• mutant females develop adenomas and adenocarcinomas earlier than mutant males and wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory