neoplasm
• increase in susceptibility to colon cancers in response to azoxymethane (AOM), developing higher total numbers of tumors and at earlier times than in controls
• mutant females develop adenomas and adenocarcinomas earlier than mutant males and wild-type mice
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digestive/alimentary system
• colonic proliferation in response to azoxymethane (AOM) is increased compared to wild-type
• aberrant crypt foci are increased by about 2-5-fold after 2 weeks of AOM treatment compared to wild-type mice
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homeostasis/metabolism
• colonic proliferation in response to azoxymethane (AOM) is increased compared to wild-type
• aberrant crypt foci are increased by about 2-5-fold after 2 weeks of AOM treatment compared to wild-type mice
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• increase in susceptibility to colon cancers in response to azoxymethane (AOM), developing higher total numbers of tumors and at earlier times than in controls
• mutant females develop adenomas and adenocarcinomas earlier than mutant males and wild-type mice
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