Phenotypes associated with this allele

• Allele Symbol: Foxa1^tm1Stf
• Allele Name: targeted mutation 1, Markus Stoffel
• Allele ID: MGI:2384404
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxa1^tm1Stf/Foxa1^tm1Stf	Not Specified	MGI:3806695
ht2	Foxa1^tm1Stf/Foxa1^+	Not Specified	MGI:3806681

Genotype
MGI:3806695

hm1

• Allelic Composition: Foxa1^tm1Stf/Foxa1^tm1Stf
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:57493 )

• mice die 2 to 14 days after birth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:57493 )

N • at 2 to 3 days after birth, cholesterol levels are normal

increased circulating cortisol level ( J:57493 )

• serum cortisol levels are increased 5-fold compared to in wild-type mice

increased circulating growth hormone level ( J:57493 )

• increased 2-fold

decreased circulating triglyceride level ( J:57493 )

• triglyceride levels are reduced 20% to 60% compared to in wild-type mice

abnormal glucose homeostasis ( J:57493 )

• pancreatic glucagons content is decreased 50% compared to in wild-type mice

decreased insulin secretion ( J:57493 )

• mice exhibit a mild defect in insulin secretion

hypoglycemia ( J:57493 )

• glucose levels are reduced 20% to 60% compared to in wild-type mice

decreased circulating glucagon level ( J:57493 )

• decreased 50%

decreased circulating insulin level ( J:57493 )

• 24 hours after starvation, serum insulin levels are decreased 50% compared to in wild-type mice

impaired glucose tolerance ( J:57493 )

• following injection of glucose, serum glucose levels are higher and insulin levels are lower than in similarly treated wild-type mice

growth/size/body

decreased body weight ( J:57493 )

postnatal growth retardation ( J:57493 )

• at 1 to 2 days after birth

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:57493 )

N • despite the reduction in pancreatic glucagons levels, pancreas development and differentiation is normal

decreased insulin secretion ( J:57493 )

• mice exhibit a mild defect in insulin secretion

Genotype
MGI:3806681

ht2

• Allelic Composition: Foxa1^tm1Stf/Foxa1⁺
• Genetic Background: Not Specified

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:138581 )

• plasma alpha HDL, pre-beta HDL and overall HDL are decreased compared to in wild-type mice