Analysis Tools
mortality/aging
|
• mice die 2 to 14 days after birth
|
homeostasis/metabolism
| N |
• at 2 to 3 days after birth, cholesterol levels are normal
|
|
• serum cortisol levels are increased 5-fold compared to in wild-type mice
|
|
• increased 2-fold
|
|
• triglyceride levels are reduced 20% to 60% compared to in wild-type mice
|
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• pancreatic glucagons content is decreased 50% compared to in wild-type mice
|
|
• mice exhibit a mild defect in insulin secretion
|
hypoglycemia
(
J:57493
)
|
• glucose levels are reduced 20% to 60% compared to in wild-type mice
|
|
• decreased 50%
|
|
• 24 hours after starvation, serum insulin levels are decreased 50% compared to in wild-type mice
|
|
• following injection of glucose, serum glucose levels are higher and insulin levels are lower than in similarly treated wild-type mice
|
growth/size/body
|
• at 1 to 2 days after birth
|
endocrine/exocrine glands
| N |
• despite the reduction in pancreatic glucagons levels, pancreas development and differentiation is normal
|
|
• mice exhibit a mild defect in insulin secretion
|
