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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Csf3rtm3Link
targeted mutation 3, Daniel C Link
MGI:2384412
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Csf3rtm3Link/Csf3rtm3Link B6.129X1-Csf3rtm3Link MGI:3836740
hm2
 		Csf3rtm3Link/Csf3rtm3Link involves: 129X1/SvJ * C57BL/6 MGI:3836777


Genotype
MGI:3836740
hm1
Allelic
Composition		 Csf3rtm3Link/Csf3rtm3Link
Genetic
Background		 B6.129X1-Csf3rtm3Link
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm3Link mutation (0 available); any Csf3r mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:79567 )
N
• mobilization in response to granulocyte-colony stimulating factor (G-CSF) is similar to controls




Genotype
MGI:3836777
hm2
Allelic
Composition		 Csf3rtm3Link/Csf3rtm3Link
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm3Link mutation (0 available); any Csf3r mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal common myeloid progenitor cell morphology ( J:67612 )
• relative accumulation of myeloid precursors observed in bone marrow
• response to granulocyte-colony stimulating factor (G-CSF) less than normal
• no G-CSF induced colonies but clusters of 10-20 cells observed
• constitutive STAT3 expression partially restores colony forming response
• colonies contain about 5% neutrophiles as compared to 40-50% neutrophiles in controls
decreased neutrophil cell number ( J:67612 )
• number of circulating neutrophils about 15% of controls
• very modest reduction in neutrophile numbers in bone marrow

immune system
decreased neutrophil cell number ( J:67612 )
• number of circulating neutrophils about 15% of controls
• very modest reduction in neutrophile numbers in bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory