Phenotypes associated with this allele

• Allele Symbol: Csf3r^tm3Link
• Allele Name: targeted mutation 3, Daniel C Link
• Allele ID: MGI:2384412
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csf3r^tm3Link/Csf3r^tm3Link	B6.129X1-Csf3r^tm3Link	MGI:3836740
hm2	Csf3r^tm3Link/Csf3r^tm3Link	involves: 129X1/SvJ * C57BL/6	MGI:3836777

Genotype
MGI:3836740

hm1

• Allelic Composition: Csf3r^tm3Link/Csf3r^tm3Link
• Genetic Background: B6.129X1-Csf3r^tm3Link

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:79567 )

N • mobilization in response to granulocyte-colony stimulating factor (G-CSF) is similar to controls

Genotype
MGI:3836777

hm2

• Allelic Composition: Csf3r^tm3Link/Csf3r^tm3Link
• Genetic Background: involves: 129X1/SvJ * C57BL/6

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:67612 )

• relative accumulation of myeloid precursors observed in bone marrow

• response to granulocyte-colony stimulating factor (G-CSF) less than normal

• no G-CSF induced colonies but clusters of 10-20 cells observed

• constitutive STAT3 expression partially restores colony forming response

• colonies contain about 5% neutrophiles as compared to 40-50% neutrophiles in controls

decreased neutrophil cell number ( J:67612 )

• number of circulating neutrophils about 15% of controls

• very modest reduction in neutrophile numbers in bone marrow

immune system

decreased neutrophil cell number ( J:67612 )

• number of circulating neutrophils about 15% of controls

• very modest reduction in neutrophile numbers in bone marrow