Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ccl11tm1Mer targeted mutation 1, Marc E Rothenberg MGI:2384435 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutant mice have markedly fewer eosinophils in the jejunum than do wild-type controls
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• mutant mice have markedly fewer eosinophils in the jejunum than do wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• total eosinophil count is reduced compared with wild-type mice
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• mutants exhibit reduced early, but not late, eosinophil recruitment after antigen challenge in models of asthma and stromal keratitis
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• total eosinophil count is reduced compared with wild-type mice
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• mutants exhibit reduced early, but not late, eosinophil recruitment after antigen challenge in models of asthma and stromal keratitis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• doubly mutant mice have 1.5-2-fold as many eosinophils in the bone marrow and peripheral blood as do wild-type 129S/SvEv mice
• doubly mutant mice have 85-fold fewer eosinophils in the jejunum than do wild-type 129S/SvEv mice
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• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice exhibit a 10-fold greater elevation in peripheral blood eosinophil counts than do similarly challenged wild-type controls
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice have 7-fold fewer eosinophils in bronchoalveolar lavage fluid (BALF) than do similarly challenged wild-type controls and significantly fewer than mice mutant only for Ccl24 (p<0.01) or Ccl11 (p<0.05); numbers of BALF noneosinophils do not differ between mutant and wild-type mice
• upon a second intranasal ovalbumin challenge after initial intraperitoneal sensitization, doubly mutant mice have 85% fewer peribronchial eosinophils than wild-type or singly mutant mice; the double mutants have eosinophils scattered in the lung parenchyma, rather than concentrated in peribronchial and perivascular inflammatory infiltrates as in wild-type and singly mutant mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• lymphocyte and macrophage accumulation in bronchoalveolar fluid is unaffected
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• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
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• eosinophils are absent in bronchoalveolar lavage fluid after Aspergillus fumigatus exposure
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• reduced mucus production after Aspergillus fumigatus exposure
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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