Phenotypes associated with this allele

• Allele Symbol: Ltb^tm1Krn
• Allele Name: targeted mutation 1, Heinrich Korner
• Allele ID: MGI:2384499
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltb^tm1Krn/Ltb^tm1Krn	C57BL/6-Ltb^tm1Krn	MGI:3768355

Genotype
MGI:3768355

hm1

• Allelic Composition: Ltb^tm1Krn/Ltb^tm1Krn
• Genetic Background: C57BL/6-Ltb^tm1Krn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:78229 )

• unlike wild-type mice, infection with Leishmania major results in skin lesions that progress to ulcers and mortality within 8 to 14 weeks

immune system

abnormal spleen morphology ( J:78229 )

• while white pulp structure and B cell follicular structures are conserved there is limited B cell penetration into T cell areas

spleen hyperplasia ( J:78229 )

• the spleen is hypercellular and double the wild-type size

absent Peyer's patches ( J:78229 )

abnormal mesenteric lymph node morphology ( J:78229 )

• 38% of mice exhibit 1 to 3 large mesenteric lymph nodes, 38% exhibit small or normal lymph nodes and 24% exhibit no lymphoid aggregates

absent cervical lymph nodes ( J:78229 )

absent peripheral lymph nodes ( J:78229 )

abnormal humoral immune response ( J:78229 )

• unlike wild-type mice, 7 days after infection with Leishmania major no specific antigen response has been mounted and only a weak T cell response is visible by 28 days

• however, immune response to Con A is normal

decreased IgG1 level ( J:78229 )

• IgG1 production during the first 3 weeks following infection with Leishmania major is lower than in wild-type mice

decreased IgG2a level ( J:78229 )

• IgG2a production during the first 3 weeks following infection with Leishmania major is virtually absent unlike in wild-type mice

increased IgM level ( J:78229 )

• IgM production during the first 3 weeks following infection with Leishmania major is higher than in wild-type mice

increased susceptibility to parasitic infection ( J:78229 )

• unlike wild-type mice, infection with Leishmania major results in skin lesions that progress to ulcers and mortality within 8 to 14 weeks

• parasite content in the spleen is 500x higher than in wild-type mice after 14 days (5 viable parasites per 1000 splenocytes compared to 0.01 viable parasites per 1000 splenocytes in wild-type mice)

hematopoietic system

abnormal spleen morphology ( J:78229 )

• while white pulp structure and B cell follicular structures are conserved there is limited B cell penetration into T cell areas

spleen hyperplasia ( J:78229 )

• the spleen is hypercellular and double the wild-type size

decreased IgG1 level ( J:78229 )

• IgG1 production during the first 3 weeks following infection with Leishmania major is lower than in wild-type mice

decreased IgG2a level ( J:78229 )

• IgG2a production during the first 3 weeks following infection with Leishmania major is virtually absent unlike in wild-type mice

increased IgM level ( J:78229 )

• IgM production during the first 3 weeks following infection with Leishmania major is higher than in wild-type mice

growth/size/body

spleen hyperplasia ( J:78229 )

• the spleen is hypercellular and double the wild-type size