Phenotypes associated with this allele

• Allele Symbol: Cxcl13^tm1Cys
• Allele Name: targeted mutation 1, Jason G Cyster
• Allele ID: MGI:2384500
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcl13^tm1Cys/Cxcl13^tm1Cys	B6.129X1-Cxcl13^tm1Cys	MGI:3702730
hm2	Cxcl13^tm1Cys/Cxcl13^tm1Cys	involves: 129X1/SvJ * C57BL/6	MGI:2673363

Genotype
MGI:3702730

hm1

• Allelic Composition: Cxcl13^tm1Cys/Cxcl13^tm1Cys
• Genetic Background: B6.129X1-Cxcl13^tm1Cys

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired B cell migration ( J:118931 )

• germinal center (GC) B cells migrate more slowly in culture than wild-type GC B cells; cells show a slower velocity and less mean displacement over time compared to wild-type cells

immune system

impaired B cell migration ( J:118931 )

• germinal center (GC) B cells migrate more slowly in culture than wild-type GC B cells; cells show a slower velocity and less mean displacement over time compared to wild-type cells

hematopoietic system

impaired B cell migration ( J:118931 )

• germinal center (GC) B cells migrate more slowly in culture than wild-type GC B cells; cells show a slower velocity and less mean displacement over time compared to wild-type cells

Genotype
MGI:2673363

hm2

• Allelic Composition: Cxcl13^tm1Cys/Cxcl13^tm1Cys
• Genetic Background: involves: 129X1/SvJ * C57BL/6

immune system

abnormal spleen B cell follicle morphology ( J:78282 )

• B cells fail to organize into polarized follicular clusters and appear as a ring of cells at the perimeter of T-cell areas

• boundary between B-cell rich areas and T zones are often poorly demarcated, with increased numbers of B cells and T cells in reciprocal areas

decreased spleen germinal center size ( J:78282 )

• germinal centers form in spleen after immunization with T-cell dependent antigen, however they are misplaced and smaller

abnormal spleen marginal zone morphology ( J:78282 )

• spleen shows a thickened ring of IgM^hiIgD^lo marginal zone B cells and the boundary between the B cells in this area and the inner ring of B cells is disrupted, with increased numbers of IgM^hiIgD^lo cells in the outer marginal zone

abnormal B cell physiology ( J:78282 )

• impaired trafficking of B cells to lymphoid follicles

absent follicular dendritic cells ( J:78282 )

• absence of primary follicular dendritic cells in spleen and lymph nodes

abnormal Peyer's patch morphology ( J:78282 )

• Peyer's patches that are observed lack the characteristic multi-domed structure

decreased Peyer's patch number ( J:78282 )

small Peyer's patches ( J:78282 )

• Peyer's patches that are observed are small

abnormal lymph node germinal center morphology ( J:78282 )

• germinal centers form in lymph nodes after immunization with T-cell dependent antigen, however they are misplaced and smaller

decreased lymph node number ( J:78282 )

• most mice lack inguinal, iliac, sacral, brachial, and axillary lymph nodes

• however, a full set of mesenteric lymph nodes is observed

absent axillary lymph nodes ( J:78282 )

• in most mice

absent brachial lymph nodes ( J:78282 )

• in most mice

absent inguinal lymph nodes ( J:78282 )

• in most mice

hematopoietic system

abnormal spleen B cell follicle morphology ( J:78282 )

• B cells fail to organize into polarized follicular clusters and appear as a ring of cells at the perimeter of T-cell areas

• boundary between B-cell rich areas and T zones are often poorly demarcated, with increased numbers of B cells and T cells in reciprocal areas

decreased spleen germinal center size ( J:78282 )

• germinal centers form in spleen after immunization with T-cell dependent antigen, however they are misplaced and smaller

abnormal spleen marginal zone morphology ( J:78282 )

• spleen shows a thickened ring of IgM^hiIgD^lo marginal zone B cells and the boundary between the B cells in this area and the inner ring of B cells is disrupted, with increased numbers of IgM^hiIgD^lo cells in the outer marginal zone

abnormal B cell physiology ( J:78282 )

• impaired trafficking of B cells to lymphoid follicles