About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lta/Tnftm1Jods
targeted mutation 1, Jonathon D Sedgwick
MGI:2384505
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6-Lta/Tnftm1Jods MGI:3768358
hm2
Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6J-Lta/Tnftm1Jods MGI:3052841
hm3
Lta/Tnftm1Jods/Lta/Tnftm1Jods involves: C57BL/6 MGI:5441221


Genotype
MGI:3768358
hm1
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
C57BL/6-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Lta mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• spleen white pulp micro-architecture is severely disrupted
• mice are resistant to the development of experimental autoimmune encephalomyelitis

hematopoietic system
• spleen white pulp micro-architecture is severely disrupted




Genotype
MGI:3052841
hm2
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
C57BL/6J-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Lta mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 4-5 fold increase in leukocytosis
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
• deficient in all serum Ig isotypes except IgM

immune system
• 4-5 fold increase in leukocytosis
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
• deficient in all serum Ig isotypes except IgM
• lacks lymph nodes

growth/size/body




Genotype
MGI:5441221
hm3
Allelic
Composition
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Lta mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells

immune system
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory