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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lta/Tnftm1Jods
targeted mutation 1, Jonathon D Sedgwick
MGI:2384506
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6-Lta/Tnftm1Jods MGI:3768359
hm2
 		Lta/Tnftm1Jods/Lta/Tnftm1Jods C57BL/6J-Lta/Tnftm1Jods MGI:3052842
hm3
 		Lta/Tnftm1Jods/Lta/Tnftm1Jods involves: C57BL/6 MGI:5441222


Genotype
MGI:3768359
hm1
Allelic
Composition		 Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background		 C57BL/6-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal spleen white pulp morphology ( J:78229 )
• spleen white pulp micro-architecture is severely disrupted
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:47428 )
• mice are resistant to the development of experimental autoimmune encephalomyelitis

hematopoietic system
abnormal spleen white pulp morphology ( J:78229 )
• spleen white pulp micro-architecture is severely disrupted




Genotype
MGI:3052842
hm2
Allelic
Composition		 Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background		 C57BL/6J-Lta/Tnftm1Jods
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased leukocyte cell number ( J:43602 )
• 4-5 fold increase in leukocytosis
enlarged spleen ( J:43602 )
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
decreased immunoglobulin level ( J:43602 )
• deficient in all serum Ig isotypes except IgM

immune system
increased leukocyte cell number ( J:43602 )
• 4-5 fold increase in leukocytosis
enlarged spleen ( J:43602 )
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells
decreased immunoglobulin level ( J:43602 )
• deficient in all serum Ig isotypes except IgM
absent lymph nodes ( J:43602 )
• lacks lymph nodes

growth/size/body
enlarged spleen ( J:43602 )
• B and T cell areas poorly demarcated and poorly organized
• deficiency of IgM-high IgD-low B cells




Genotype
MGI:5441222
hm3
Allelic
Composition		 Lta/Tnftm1Jods/Lta/Tnftm1Jods
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Jods mutation (0 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal gamma-delta T cell morphology ( J:169863 )
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells

immune system
abnormal gamma-delta T cell morphology ( J:169863 )
• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory