All Phenotypes Stat3<tm1Vpo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpn11^tm1Gsf/Ptpn11^tm1Gsf Stat3^tm1Vpo/Stat3^tm1Vpo Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:5009547
cn2	Stat3^tm1Vpo/Stat3^tm1Vpo Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA	MGI:3040656
cn3	Stat3^tm1Vpo/Stat3^tm1Vpo Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5009548
cn4	Stat3^tm1Vpo/Stat3⁺ Tg(Myh6-cre)2182Mds/0	involves: 129P2/OlaHsd * FVB/N	MGI:5906909
cn5	Stat3^tm1Vpo/Stat3^tm1Vpo Tg(Myh6-cre)2182Mds/0	involves: 129P2/OlaHsd * FVB/N	MGI:5906908
cn6	Stat3^tm1Vpo/Stat3^tm2Vpo Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA * BALB/cAn	MGI:3040651

Allelic Composition	Ptpn11^tm1Gsf/Ptpn11^tm1Gsf Stat3^tm1Vpo/Stat3^tm1Vpo Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11^tm1Gsf mutation (0 available); any Ptpn11 mutation (44 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Stat3^tm1Vpo mutation (0 available); any Stat3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:172422 )

• increase in serum ALT levels, however ALT levels are lower than in single conditional Ptpn11 mice

increased incidence of tumors by chemical induction ( J:172422 )

• mutants exhibit an increase in hepatocellular carcinoma development after diethylnitrosamine (DEN) injection compared to controls and single conditional Ptpn11 mutants, however tumor frequency and size are similar to that seen in single conditional Stat3 mutants

immune system

liver inflammation ( J:172422 )

• infiltrate of inflammatory cells is seen in the portal triads of livers

• double mutants show less inflammation than seen in single conditional Ptpn11 mice, with reduced size of eosinophilic vacuoles of degeneration in the liver

liver/biliary system

liver inflammation ( J:172422 )

• infiltrate of inflammatory cells is seen in the portal triads of livers

• double mutants show less inflammation than seen in single conditional Ptpn11 mice, with reduced size of eosinophilic vacuoles of degeneration in the liver

neoplasm

increased incidence of tumors by chemical induction ( J:172422 )

Allelic Composition	Stat3^tm1Vpo/Stat3^tm1Vpo Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Vpo mutation (0 available); any Stat3 mutation (70 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:89194 )

• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

increased interleukin-6 secretion ( J:89194 )

• increased IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

increased tumor necrosis factor secretion ( J:89194 )

• increased TNF production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

hematopoietic system

abnormal macrophage physiology ( J:89194 )

• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

Allelic Composition	Stat3^tm1Vpo/Stat3^tm1Vpo Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Stat3^tm1Vpo mutation (0 available); any Stat3 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:172422 )

• mutants exhibit an increase in hepatocellular carcinoma development (increase in tumor number and size) after diethylnitrosamine (DEN) injection compared to controls

neoplasm

increased incidence of tumors by chemical induction ( J:172422 )

• mutants exhibit an increase in hepatocellular carcinoma development (increase in tumor number and size) after diethylnitrosamine (DEN) injection compared to controls

Allelic Composition	Stat3^tm1Vpo/Stat3⁺ Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Vpo mutation (0 available); any Stat3 mutation (70 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

pregnancy-related premature death ( J:141591 )

• postpartum cardiomyopathy-related death is seen after 3-4 deliveries

cardiovascular system

cardiomyopathy ( J:141591 )

• females develop postpartum cardiomyopathy

congestive heart failure ( J:141591 )

• after 4 pregnancies, the majority of females show signs of overt heart failure such as generalized edema and labored breathing

homeostasis/metabolism

generalized edema ( J:141591 )

• females exhibit generalized edema after 4 pregnancies

muscle

cardiomyopathy ( J:141591 )

• females develop postpartum cardiomyopathy

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

pregnancy-related premature death ( J:141591 )

• no females survive more than 5 pregnancies

• about 2/3 of females die after the second pregnancy

• death always occurs within the first 3 weeks after delivery

cardiovascular system

abnormal angiogenesis ( J:141591 )

• myocardial angiogenesis is impaired in postpartum females, with mice showing reduced left ventricle capillary density postpartum compared to controls

abnormal myocardial fiber morphology ( J:141591 )

• increase in cardiomyocyte length in postpartum females

cardiac fibrosis ( J:141591 )

• extensive cardiac fibrosis in postpartum females

dilated heart ( J:141591 )

• 4-chamber dilatation in postpartum females

dilated heart left ventricle ( J:141591 )

decreased cardiac muscle contractility ( J:141591 )

• depressed fractional shorting in postpartum females

abnormal heart echocardiography feature ( J:141591 )

• echocardiography indicates left ventricular dilatation and depressed fractional shorting in postpartum females

cardiomyopathy ( J:141591 )

• all females develop postpartum cardiomyopathy

• treatment with tetrakis (4-benzoic acid) porphyrin (MnTBAP), a pharmacological suppressor of ROS, partially suppresses postpartum cardiomyopathy

• treatment with bromocriptine, a dopamine-D2-receptor agonist and inhibitor of prolactin secretion, prevents postpartum cardiomyopathy and mortality in females

congestive heart failure ( J:141591 )

• after 2 pregnancies, the majority of females show signs of overt heart failure such as generalized edema and labored breathing

cellular

increased cardiomyocyte apoptosis ( J:141591 )

• cardiac apoptosis is increased in postpartum females

oxidative stress ( J:141591 )

• hearts of postpartum females exhibit increased oxidative stress

homeostasis/metabolism

abnormal atrial thrombosis ( J:141591 )

• thrombi are often seen in the atria of postpartum females

generalized edema ( J:141591 )

• females exhibit generalized edema after 2 pregnancies

muscle

abnormal myocardial fiber morphology ( J:141591 )

• increase in cardiomyocyte length in postpartum females

decreased cardiac muscle contractility ( J:141591 )

• depressed fractional shorting in postpartum females

cardiomyopathy ( J:141591 )

• all females develop postpartum cardiomyopathy

• treatment with tetrakis (4-benzoic acid) porphyrin (MnTBAP), a pharmacological suppressor of ROS, partially suppresses postpartum cardiomyopathy

• treatment with bromocriptine, a dopamine-D2-receptor agonist and inhibitor of prolactin secretion, prevents postpartum cardiomyopathy and mortality in females

increased cardiomyocyte apoptosis ( J:141591 )

• cardiac apoptosis is increased in postpartum females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
peripartum cardiomyopathy		DOID:9997		J:141591

Allelic Composition	Stat3^tm1Vpo/Stat3^tm2Vpo Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA * BALB/cAn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3^tm1Vpo mutation (0 available); any Stat3 mutation (70 available)
Stat3^tm2Vpo mutation (0 available); any Stat3 mutation (70 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal macrophage physiology ( J:89194 )

• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

increased interleukin-6 secretion ( J:89194 )

• increased IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

increased tumor necrosis factor secretion ( J:89194 )

• increased TNF production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

hematopoietic system

abnormal macrophage physiology ( J:89194 )

• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

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