All Phenotypes H2-DMa<tm1Doi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H2-DMa^tm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:2384509

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-DMa^tm1Doi/H2-DMa^tm1Doi	involves: 129S2/SvPas * C57BL/6	MGI:2386163
cx2	Cd74^tm1Doi/Cd74^tm1Doi H2-DMa^tm1Doi/H2-DMa^tm1Doi	involves: 129S2/SvPas * C57BL/6	MGI:2386166

Allelic Composition	H2-DMa^tm1Doi/H2-DMa^tm1Doi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-DMa^tm1Doi mutation (1 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:31624 )

N	• positive selection of CD4+ T cells effective, yielding large and broad repertoire

abnormal professional antigen presenting cell physiology ( J:31624 )

• antigen presenting cells (APCs) had defective protein and peptide presentation

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi H2-DMa^tm1Doi/H2-DMa^tm1Doi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)
H2-DMa^tm1Doi mutation (1 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:42482 )

• significant mortality after a few weeks of age

growth/size/body

decreased body size ( J:42482 )

• showed runting

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:42482 )

• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population

increased CD8-positive, alpha-beta T cell number ( J:42482 )

• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population