Phenotypes associated with this allele

• Allele Symbol: Kcna5^{tm1(Kcna1)Lndn}
• Allele Name: targeted mutation 1, Barry London
• Allele ID: MGI:2384510
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcna5^tm1(Kcna1)Lndn/Kcna5^tm1(Kcna1)Lndn	involves: C57BL/6	MGI:3583141

Genotype
MGI:3583141

hm1

• Allelic Composition: Kcna5^{tm1(Kcna1)Lndn}/Kcna5^{tm1(Kcna1)Lndn}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular smooth muscle physiology ( J:70694 )

• pulmonary artery smooth muscle cells with lower normoxic current density than controls

decreased vasoconstriction ( J:70694 )

• hypoxic pulmonary vasoconstriction significantly reduced

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:78122 )

• insensitive to 4-aminopyridine indcued changes in cardiac rhythm

muscle

abnormal vascular smooth muscle physiology ( J:70694 )

• pulmonary artery smooth muscle cells with lower normoxic current density than controls

decreased vasoconstriction ( J:70694 )

• hypoxic pulmonary vasoconstriction significantly reduced