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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scnn1atm1.1Hum
targeted mutation 1.1, Edith Hummler
MGI:2384527
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Scnn1atm1.1Hum/Scnn1atm1.1Hum involves: 129 MGI:2386275
cn2
Scnn1atm1.1Hum/Scnn1atm1.1Hum
Tg(Hoxb7-cre)13Amc/0
involves: 129/Sv * C57BL/6 MGI:4460805


Genotype
MGI:2386275
hm1
Allelic
Composition
Scnn1atm1.1Hum/Scnn1atm1.1Hum
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnn1atm1.1Hum mutation (1 available); any Scnn1a mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4460805
cn2
Allelic
Composition
Scnn1atm1.1Hum/Scnn1atm1.1Hum
Tg(Hoxb7-cre)13Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scnn1atm1.1Hum mutation (1 available); any Scnn1a mutation (28 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• when mice are fed a normal sodium diet, cortical collecting ducts exhibit no significant sodium, chloride, or potassium ion transport unlike wild-type ducts from similarly treated wild-type mice
• when mice are fed a sodium-depleted diet, cortical collecting ducts absorb sodium without forming a lumen-negative transepithelial voltage unlike ducts from similarly treated wild-type mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory