Phenotypes associated with this allele

• Allele Symbol: Tg(GAS)2Tcw
• Allele Name: transgene insertion 2, Timothy C Wang
• Allele ID: MGI:2384541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(GAS)2Tcw/0	involves: FVB/N	MGI:2665286

Genotype
MGI:2665286

tg1

• Allelic Composition: Tg(GAS)2Tcw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:63579 )

• greater incidence and numbers of azoxymethane (AOM)-induced colon carcinomas and deaths than in controls

• large percentage of tumors (40%) are present in the proximal segment of the colon, whereas less than 10% of tumors in wild-type mice are in this segment and most are in the distal colon

• higher percentage of large and medium sized tumors than in wild-type mice

homeostasis/metabolism

abnormal blood homeostasis ( J:63579 )

• blood levels of progastrin are higher than in wild-type

increased incidence of tumors by chemical induction ( J:63579 )

• greater incidence and numbers of azoxymethane (AOM)-induced colon carcinomas and deaths than in controls

• large percentage of tumors (40%) are present in the proximal segment of the colon, whereas less than 10% of tumors in wild-type mice are in this segment and most are in the distal colon

• higher percentage of large and medium sized tumors than in wild-type mice

behavior/neurological

increased aggression ( J:63579 )

• males are extremely aggressive