Phenotypes associated with this allele

• Allele Symbol: Ldha^a-m1Neu
• Allele Name: mutation 1, Neuherberg
• Allele ID: MGI:2384559
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ldha^a-m1Neu/Ldha^a-m1Neu	C3.Cg-Ldha^a-m1Neu	MGI:3776411
hm2	Ldha^a-m1Neu/Ldha^a-m1Neu	involves: 101/El * C3H/El	MGI:3776789
cx3	Ldha^a-m1Neu/Ldha^a-m1Neu Tg(IGL-MYC)3Hm/0	involves: 101/El * C3H/El * C57BL/6N	MGI:5426847

Genotype
MGI:3776411

hm1

• Allelic Composition: Ldha^a-m1Neu/Ldha^a-m1Neu
• Genetic Background: C3.Cg-Ldha^a-m1Neu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hemolytic anemia ( J:14326 )

decreased erythrocyte cell number ( J:14326 )

decreased hematocrit ( J:14326 )

decreased hemoglobin content ( J:14326 )

reticulocytosis ( J:14326 )

homeostasis/metabolism

increased circulating bilirubin level ( J:14326 )

cardiovascular system

increased heart weight ( J:14326 )

liver/biliary system

increased liver weight ( J:14326 )

respiratory system

increased lung weight ( J:14326 )

growth/size/body

increased heart weight ( J:14326 )

increased lung weight ( J:14326 )

increased liver weight ( J:14326 )

Genotype
MGI:3776789

hm2

• Allelic Composition: Ldha^a-m1Neu/Ldha^a-m1Neu
• Genetic Background: involves: 101/El * C3H/El

hematopoietic system

increased spleen weight ( J:132674 )

• 7 times higher than wild-type

spleen hyperplasia ( J:132674 )

• 14 times higher than wild-type

abnormal common myeloid progenitor cell morphology ( J:132674 )

• the number of hematopoietic stem cells from spleen samples is increased 9-fold where as the number from bone marrow is slightly reduced compared to in wild-type mice

• the number of late erythrocyte progenitors from bone marrow is decreased 2-fold while the number of late erythrocyte progenitors from the spleen is increased 50-fold compared to in wild-type mice

• the number of myeloid and early progenitor cells is from the spleen is increased 20 times compared to in wild-type mice

• total early myeloid progenitor pools are increased 1.4-fold where as total late myeloid progenitor pools are increased 18-fold compared to in wild-type mice

• polychromatic erythroblasts exhibit reduced proliferation compared to wild-type cells

hemolytic anemia ( J:132674 )

• severe

abnormal erythrocyte morphology ( J:132674 )

• red blood cells are more sensitive to gamma irradiation than wild-type red blood cells

decreased erythrocyte cell number ( J:132674 )

decreased hematocrit ( J:132674 )

decreased hemoglobin content ( J:132674 )

increased mean corpuscular volume ( J:132674 )

reticulocytosis ( J:132674 )

abnormal leukocyte morphology ( J:132674 )

• the ratio of granulocytes to lymphocytes is altered

increased neutrophil cell number ( J:132674 )

immune system

increased spleen weight ( J:132674 )

• 7 times higher than wild-type

spleen hyperplasia ( J:132674 )

• 14 times higher than wild-type

abnormal leukocyte morphology ( J:132674 )

• the ratio of granulocytes to lymphocytes is altered

increased neutrophil cell number ( J:132674 )

growth/size/body

increased spleen weight ( J:132674 )

• 7 times higher than wild-type

spleen hyperplasia ( J:132674 )

• 14 times higher than wild-type

Genotype
MGI:5426847

cx3

• Allelic Composition: Ldha^a-m1Neu/Ldha^a-m1Neu; Tg(IGL-MYC)3Hm/0
• Genetic Background: involves: 101/El * C3H/El * C57BL/6N

neoplasm

increased tumor growth/size ( J:183477 )

• mice exhibit accelerated tumorigenesis compared with Tg(IGL-MYC)3Hm mice