neoplasm
• although mutants appear outwardly healthy at 5-8 months of age, they show features of bladder carcinoma in situ (CIS), including moderate-to-severe urothelial atypia with marked nuclear pleomophism such as giant nuclei and abundant mitotic figures
• CIS lesions do not progress to transitional cell carcinoma (TCC) by 8 months of age
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renal/urinary system
• although mutants appear outwardly healthy at 5-8 months of age, they show features of bladder carcinoma in situ (CIS), including moderate-to-severe urothelial atypia with marked nuclear pleomophism such as giant nuclei and abundant mitotic figures
• CIS lesions do not progress to transitional cell carcinoma (TCC) by 8 months of age
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