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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT5-E2F1)2Dgj
transgene insertion 2, David G Johnson
MGI:2384616
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-cre)5132Jlj/0
Tg(KRT5-E2F1)2Dgj/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:2677036
cx2
 		Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-E2F1)2Dgj/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:2677035
cx3
 		Brca1tm2Cxd/Brca1+
Tg(KRT5-E2F1)2Dgj/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3836053
tg4
 		Tg(KRT5-E2F1)2Dgj/? involves: C57BL/6 * SJL/J *SKH1 MGI:3840840


Genotype
MGI:2677036
cn1
Allelic
Composition		 Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-cre)5132Jlj/0
Tg(KRT5-E2F1)2Dgj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (114 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
Tg(KRT5-E2F1)2Dgj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:85354 )
• fewer (6.25%) than the expected 12.5% of mutants were observed, indicating some lethality; time of analysis not specified

neoplasm
increased skin tumor incidence ( J:85354 )
• by 45 weeks of age, all mutants develop at least one skin tumor, with an average of four tumors per mouse
increased squamous cell carcinoma incidence ( J:85354 )
• skin tumors are all squamous cell carcinoma
decreased tumor latency ( J:85354 )
• all mutants develop tumors by 45 weeks of age, significantly sooner than Brca1tm1Cxd/Brca1tm2Cxd Tg(KRT5-cre)1Jlj/0 mice or Brca1tm2Cxd/Brca1+ Tg(KRT5-cre)1Jlj/0 mice and by 70 weeks of age, 100% of mice exhibit tumors

integument
increased keratinocyte proliferation ( J:85354 )
• increase in basal keratinocyte proliferation
abnormal epidermal layer morphology ( J:85354 )
• mutants exhibit increased epidermal proliferation and apoptosis
increased skin tumor incidence ( J:85354 )
• by 45 weeks of age, all mutants develop at least one skin tumor, with an average of four tumors per mouse

cellular
increased keratinocyte proliferation ( J:85354 )
• increase in basal keratinocyte proliferation




Genotype
MGI:2677035
cx2
Allelic
Composition		 Brca1tm1Cxd/Brca1tm2Cxd
Tg(KRT5-E2F1)2Dgj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Cxd mutation (1 available); any Brca1 mutation (114 available)
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (114 available)
Tg(KRT5-E2F1)2Dgj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:85354 )
• 94.7% of mutants develop tumors at 70 weeks of age
increased mouth tumor incidence ( J:85354 )
• some females develop tumors in the oral epithelium
increased skin tumor incidence ( J:85354 )
• develop tumors in the skin
increased squamous cell carcinoma incidence ( J:85354 )
• females develop squamous cell carcinoma in the cervix and vaginal epithelium
increased papilloma incidence ( J:85354 )
• females develop papillomas in the cervix
increased reproductive system tumor incidence ( J:85354 )
• develop tumors of the reproductive tract; all females develop tumors, with the majority from the cervix (papillomas and squamous cell carcinoma) and vaginal epithelium (squamous cell carcinoma)

integument
increased keratinocyte proliferation ( J:85354 )
• increase in basal keratinocyte proliferation
abnormal epidermal layer morphology ( J:85354 )
• mutants exhibit increased epidermal proliferation and apoptosis
increased skin tumor incidence ( J:85354 )
• develop tumors in the skin

cellular
increased keratinocyte proliferation ( J:85354 )
• increase in basal keratinocyte proliferation

reproductive system
increased reproductive system tumor incidence ( J:85354 )
• develop tumors of the reproductive tract; all females develop tumors, with the majority from the cervix (papillomas and squamous cell carcinoma) and vaginal epithelium (squamous cell carcinoma)

craniofacial
increased mouth tumor incidence ( J:85354 )
• some females develop tumors in the oral epithelium

growth/size/body
increased mouth tumor incidence ( J:85354 )
• some females develop tumors in the oral epithelium




Genotype
MGI:3836053
cx3
Allelic
Composition		 Brca1tm2Cxd/Brca1+
Tg(KRT5-E2F1)2Dgj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (114 available)
Tg(KRT5-E2F1)2Dgj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:85354 )
• mutants develop tumors after 1 year of age and by 70 weeks, 50% of mutants have tumors
increased skin tumor incidence ( J:85354 )
• majority of tumors occur in the skin
increased squamous cell carcinoma incidence ( J:85354 )
• majority of tumors are squamous cell carcinoma

integument
increased keratinocyte proliferation ( J:85354 )
• increase in basal keratinocyte proliferation
abnormal epidermal layer morphology ( J:85354 )
• mutants exhibit increased epidermal proliferation and apoptosis
increased skin tumor incidence ( J:85354 )
• majority of tumors occur in the skin

cellular
increased keratinocyte proliferation ( J:85354 )
• increase in basal keratinocyte proliferation




Genotype
MGI:3840840
tg4
Allelic
Composition		 Tg(KRT5-E2F1)2Dgj/?
Genetic
Background		 involves: C57BL/6 * SJL/J *SKH1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
decreased sensitivity to skin irradiation ( J:97525 )
• significantly fewer "sunburned cells" at a given UVB dose than for controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory