About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2-Ab1b-tm1Koni
targeted mutation 1, Pandelakis A Koni
MGI:2384629
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		H2-Ab1b-tm1Koni/H2-Ab1b-tm1Koni involves: 129X1/SvJ * C57BL/6J MGI:2386326
cn2
 		H2-Ab1b-tm1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0 		involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J MGI:5285614


Genotype
MGI:2386326
cn1
Allelic
Composition		 H2-Ab1b-tm1Koni/H2-Ab1b-tm1Koni
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Koni mutation (2 available); any H2-Ab1 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5285614
cn2
Allelic
Composition		 H2-Ab1b-tm1Koni/H2-Ab1b-tm1.1Koni
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1.1Koni mutation (0 available); any H2-Ab1 mutation (83 available)
H2-Ab1b-tm1Koni mutation (2 available); any H2-Ab1 mutation (83 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131774 )
N
• T regulatory cells exhibit division in response to IL2
• CD4+CD25+ exhibit effective suppressive activity
increased CD4-positive, alpha-beta T cell number ( J:131774 )
• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:131774 )
• CD4+CD25+ fopx3high T regulatory cells exhibit reduced CD25 expression compared with control cells
abnormal T cell activation ( J:131774 )
• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice
decreased level of surface class II molecules ( J:131774 )
• in splenic hemopoietic cells (B cells, CD8a- dendritic cells, and CD8a+ dendritic cells) and Langerhans cells

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:131774 )
• 1.5- to 2-fold in CD4+CD8- but not CD8-CD4+CD25+
abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:131774 )
• CD4+CD25+ fopx3high T regulatory cells exhibit reduced CD25 expression compared with control cells
abnormal T cell activation ( J:131774 )
• mice exhibit a reduced number of preactivated CD4 T cells and CD4+CD25+ cells compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory