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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KLK4mHEL)6Ccg
transgene insertion 6, Christopher C Goodnow
MGI:2384632
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0 		C57BL/6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg MGI:3793443
cx2
 		Tlr4Lps-d/Tlr4Lps-d
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0 		involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6 MGI:3694809
cx3
 		Tlr9tm1Aki/Tlr9tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694807
cx4
 		Myd88tm1Aki/Myd88tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694808
cx5
 		Prkcdtm1Qxu/Prkcdtm1Qxu
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3841844
cx6
 		Tg(IghelMD4)4Ccg/?
Tg(KLK4mHEL)6Ccg/? 		involves: C57BL/6 MGI:3799746
cx7
 		Tg(KLK4mHEL)6Ccg/0
Tg(TcrHEL3A9)1Mmd/0 		involves: C57BL/6 * C57BL/10 * C57BR/cd MGI:3799688
cx8
 		Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0 		NOD.B6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg/Dvs MGI:3793442
tg9
 		Tg(KLK4mHEL)6Ccg/? involves: C57BL/6 MGI:3799745


Genotype
MGI:3793443
cx1
Allelic
Composition		 Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background		 C57BL/6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:89156 )
• the number of B cells found in the spleen is decreased by more than 6-fold compared to mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 5.9% of that found in singly transgenic NOD mice carrying only the antibody transgene

hematopoietic system
decreased B cell number ( J:89156 )
• the number of B cells found in the spleen is decreased by more than 6-fold compared to mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 5.9% of that found in singly transgenic NOD mice carrying only the antibody transgene




Genotype
MGI:3694809
cx2
Allelic
Composition		 Tlr4Lps-d/Tlr4Lps-d
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
Tlr4Lps-d mutation (7 available); any Tlr4 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B-1 B cell number ( J:115059 )
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants
decreased B cell number ( J:115059 )
• a 35% reduction in number of recirculating mature autoreactive B cells is observed, compared to wild-type

immune system
increased B-1 B cell number ( J:115059 )
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants
decreased B cell number ( J:115059 )
• a 35% reduction in number of recirculating mature autoreactive B cells is observed, compared to wild-type




Genotype
MGI:3694807
cx3
Allelic
Composition		 Tlr9tm1Aki/Tlr9tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
Tlr9tm1Aki mutation (7 available); any Tlr9 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mature B cell number ( J:115059 )
• a 37% reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
increased B-1 B cell number ( J:115059 )
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants

immune system
decreased mature B cell number ( J:115059 )
• a 37% reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
increased B-1 B cell number ( J:115059 )
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants




Genotype
MGI:3694808
cx4
Allelic
Composition		 Myd88tm1Aki/Myd88tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation (9 available); any Myd88 mutation (50 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased mature B cell number ( J:115059 )
• a reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
increased B-1 B cell number ( J:115059 )
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants

immune system
decreased mature B cell number ( J:115059 )
• a reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
increased B-1 B cell number ( J:115059 )
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants




Genotype
MGI:3841844
cx5
Allelic
Composition		 Prkcdtm1Qxu/Prkcdtm1Qxu
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcdtm1Qxu mutation (0 available); any Prkcd mutation (52 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:76134 )
N
• mice exhibit the same number of B cells as in Tg(IghelMD4)4Ccg mice indicating normal clonal deletion




Genotype
MGI:3799746
cx6
Allelic
Composition		 Tg(IghelMD4)4Ccg/?
Tg(KLK4mHEL)6Ccg/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased immature B cell number ( J:78307 )
• a small increase occurs in the number of B220low immature B cells found in the bone marrow
arrested B cell differentiation ( J:78307 )
• the immature B cells found in the bone marrow have low surface expression of IgM suggesting B cells have encountered antigen but failed to develop to a mature phenotype
decreased mature B cell number ( J:78307 )
• mature B cells are reduced 5- to 20- fold in the bone marrow, spleen and lymph node
• the small number of mature B cells present have B cell receptors encoded by endogenous heavy chain

hematopoietic system
increased immature B cell number ( J:78307 )
• a small increase occurs in the number of B220low immature B cells found in the bone marrow
arrested B cell differentiation ( J:78307 )
• the immature B cells found in the bone marrow have low surface expression of IgM suggesting B cells have encountered antigen but failed to develop to a mature phenotype
decreased mature B cell number ( J:78307 )
• mature B cells are reduced 5- to 20- fold in the bone marrow, spleen and lymph node
• the small number of mature B cells present have B cell receptors encoded by endogenous heavy chain




Genotype
MGI:3799688
cx7
Allelic
Composition		 Tg(KLK4mHEL)6Ccg/0
Tg(TcrHEL3A9)1Mmd/0
Genetic
Background		 involves: C57BL/6 * C57BL/10 * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KLK4mHEL)6Ccg mutation (2 available)
Tg(TcrHEL3A9)1Mmd mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:78309 )
• there is a reduced number of CD4-positive thymocytes bearing the transgenic TCR
• the number of lymph node CD4 T cells bearing a transgenic TCR is reduced 10-fold compared to mice transgenic just for the TCR

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:78309 )
• there is a reduced number of CD4-positive thymocytes bearing the transgenic TCR
• the number of lymph node CD4 T cells bearing a transgenic TCR is reduced 10-fold compared to mice transgenic just for the TCR




Genotype
MGI:3793442
cx8
Allelic
Composition		 Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background		 NOD.B6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:89156 )
• the number of B cells found in the spleen is decreased by more than 6-fold compared to NOD mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 1.1% of that found in singly transgenic NOD mice carrying only the antibody transgene

hematopoietic system
decreased B cell number ( J:89156 )
• the number of B cells found in the spleen is decreased by more than 6-fold compared to NOD mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 1.1% of that found in singly transgenic NOD mice carrying only the antibody transgene




Genotype
MGI:3799745
tg9
Allelic
Composition		 Tg(KLK4mHEL)6Ccg/?
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KLK4mHEL)6Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:78307 )
• no abnormalities are observed despite widespread expression of hen egg lysozyme on the surface of numerous cells




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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory