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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KLK4mHEL)6Ccg
transgene insertion 6, Christopher C Goodnow
MGI:2384632
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
C57BL/6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg MGI:3793443
cx2
Tlr4Lps-d/Tlr4Lps-d
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6 MGI:3694809
cx3
Tlr9tm1Aki/Tlr9tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3694807
cx4
Myd88tm1Aki/Myd88tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3694808
cx5
Prkcdtm1Qxu/Prkcdtm1Qxu
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3841844
cx6
Tg(IghelMD4)4Ccg/?
Tg(KLK4mHEL)6Ccg/?
involves: C57BL/6 MGI:3799746
cx7
Tg(KLK4mHEL)6Ccg/0
Tg(TcrHEL3A9)1Mmd/0
involves: C57BL/6 * C57BL/10 * C57BR/cd MGI:3799688
cx8
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
NOD.B6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg/Dvs MGI:3793442
tg9
Tg(KLK4mHEL)6Ccg/? involves: C57BL/6 MGI:3799745


Genotype
MGI:3793443
cx1
Allelic
Composition
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background
C57BL/6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of B cells found in the spleen is decreased by more than 6-fold compared to mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 5.9% of that found in singly transgenic NOD mice carrying only the antibody transgene

hematopoietic system
• the number of B cells found in the spleen is decreased by more than 6-fold compared to mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 5.9% of that found in singly transgenic NOD mice carrying only the antibody transgene




Genotype
MGI:3694809
cx2
Allelic
Composition
Tlr4Lps-d/Tlr4Lps-d
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
Tlr4Lps-d mutation (7 available); any Tlr4 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants
• a 35% reduction in number of recirculating mature autoreactive B cells is observed, compared to wild-type

immune system
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants
• a 35% reduction in number of recirculating mature autoreactive B cells is observed, compared to wild-type




Genotype
MGI:3694807
cx3
Allelic
Composition
Tlr9tm1Aki/Tlr9tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
Tlr9tm1Aki mutation (7 available); any Tlr9 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a 37% reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants

immune system
• a 37% reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants




Genotype
MGI:3694808
cx4
Allelic
Composition
Myd88tm1Aki/Myd88tm1Aki
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation (9 available); any Myd88 mutation (52 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants

immune system
• a reduction in number of recirculating mature autoreactive B cells is observed compared to wild-type
• more B1 cells are detected among peritoneal lymphocytes in double transgenic mutants compared to Tg(IghelMD4)4Ccg single transgenic mutants




Genotype
MGI:3841844
cx5
Allelic
Composition
Prkcdtm1Qxu/Prkcdtm1Qxu
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcdtm1Qxu mutation (0 available); any Prkcd mutation (54 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit the same number of B cells as in Tg(IghelMD4)4Ccg mice indicating normal clonal deletion




Genotype
MGI:3799746
cx6
Allelic
Composition
Tg(IghelMD4)4Ccg/?
Tg(KLK4mHEL)6Ccg/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• a small increase occurs in the number of B220low immature B cells found in the bone marrow
• the immature B cells found in the bone marrow have low surface expression of IgM suggesting B cells have encountered antigen but failed to develop to a mature phenotype
• mature B cells are reduced 5- to 20- fold in the bone marrow, spleen and lymph node
• the small number of mature B cells present have B cell receptors encoded by endogenous heavy chain

hematopoietic system
• a small increase occurs in the number of B220low immature B cells found in the bone marrow
• the immature B cells found in the bone marrow have low surface expression of IgM suggesting B cells have encountered antigen but failed to develop to a mature phenotype
• mature B cells are reduced 5- to 20- fold in the bone marrow, spleen and lymph node
• the small number of mature B cells present have B cell receptors encoded by endogenous heavy chain




Genotype
MGI:3799688
cx7
Allelic
Composition
Tg(KLK4mHEL)6Ccg/0
Tg(TcrHEL3A9)1Mmd/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KLK4mHEL)6Ccg mutation (2 available)
Tg(TcrHEL3A9)1Mmd mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a reduced number of CD4-positive thymocytes bearing the transgenic TCR
• the number of lymph node CD4 T cells bearing a transgenic TCR is reduced 10-fold compared to mice transgenic just for the TCR

hematopoietic system
• there is a reduced number of CD4-positive thymocytes bearing the transgenic TCR
• the number of lymph node CD4 T cells bearing a transgenic TCR is reduced 10-fold compared to mice transgenic just for the TCR




Genotype
MGI:3793442
cx8
Allelic
Composition
Tg(IghelMD4)4Ccg/0
Tg(KLK4mHEL)6Ccg/0
Genetic
Background
NOD.B6-Tg(IghelMD4)4Ccg Tg(KLK4mHEL)6Ccg/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(KLK4mHEL)6Ccg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of B cells found in the spleen is decreased by more than 6-fold compared to NOD mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 1.1% of that found in singly transgenic NOD mice carrying only the antibody transgene

hematopoietic system
• the number of B cells found in the spleen is decreased by more than 6-fold compared to NOD mice carrying just the antibody transgene
• very few of the remaining B cells expresses the transgenic antibody
• the number of B cells expressing the transgenic antibody is 1.1% of that found in singly transgenic NOD mice carrying only the antibody transgene




Genotype
MGI:3799745
tg9
Allelic
Composition
Tg(KLK4mHEL)6Ccg/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KLK4mHEL)6Ccg mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormalities are observed despite widespread expression of hen egg lysozyme on the surface of numerous cells





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory