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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gfaptm4Ito
targeted mutation 4, Shigeyoshi Itohara
MGI:2384721
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gfaptm4Ito/Gfaptm4Ito either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3790658
cx2
Gfaptm4Ito/Gfaptm4Ito
Vimtm1Cba/Vimtm1Cba
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6) MGI:3790659


Genotype
MGI:3790658
hm1
Allelic
Composition
Gfaptm4Ito/Gfaptm4Ito
Genetic
Background
either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm4Ito mutation (1 available); any Gfap mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• cultured E18.5 neurons have glial fibrillary acidic protein-immunoreactive filaments in astrocytes are sparse, irregularly arrayed, and sometimes disrupted
• decreased glial fibrillary acidic protein (GFAP) immunoreactivity is more severe than in Gfap-single mutants




Genotype
MGI:3790659
cx2
Allelic
Composition
Gfaptm4Ito/Gfaptm4Ito
Vimtm1Cba/Vimtm1Cba
Genetic
Background
either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm4Ito mutation (1 available); any Gfap mutation (48 available)
Vimtm1Cba mutation (2 available); any Vim mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decreased glial fibrillary acidic protein (GFAP) immunoreactivity is more severe than in Gfap-single mutants
• cultured E18.5 neurons have glial fibrillary acidic protein-immunoreactive filaments in astrocytes are sparse, irregularly arrayed, and sometimes disrupted
• dot-like aggregate structures appear in cultured E18.5 astrocytes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory