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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hfetm1.1Nca
targeted mutation 1.1, Nancy C Andrews
MGI:2385350
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hfetm1.1Nca/Hfetm1.1Nca involves: 129S6/SvEvTac MGI:2655512
hm2
Hfetm1.1Nca/Hfetm1.1Nca involves: 129S6/SvEvTac * C57BL/6J MGI:2655513
hm3
Hfetm1.1Nca/Hfetm1.1Nca Not Specified MGI:2655503
cx4
Hfetm1.1Nca/Hfetm1.1Nca
Tfrctm1Nca/Tfrc+
Not Specified MGI:2655504


Genotype
MGI:2655512
hm1
Allelic
Composition
Hfetm1.1Nca/Hfetm1.1Nca
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1.1Nca mutation (1 available); any Hfe mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
• less iron accumulation than in Hfetm2Nca homozygous mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
J:78536




Genotype
MGI:2655513
hm2
Allelic
Composition
Hfetm1.1Nca/Hfetm1.1Nca
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1.1Nca mutation (1 available); any Hfe mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
• less iron accumulation than in Hfetm2Nca homozygous mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
J:78536




Genotype
MGI:2655503
hm3
Allelic
Composition
Hfetm1.1Nca/Hfetm1.1Nca
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1.1Nca mutation (1 available); any Hfe mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

liver/biliary system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
J:62112




Genotype
MGI:2655504
cx4
Allelic
Composition
Hfetm1.1Nca/Hfetm1.1Nca
Tfrctm1Nca/Tfrc+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1.1Nca mutation (1 available); any Hfe mutation (35 available)
Tfrctm1Nca mutation (1 available); any Tfrc mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• greater hepatic iron loading than than the single Hfetm1.1Nca homozygous mutant

liver/biliary system
• greater hepatic iron loading than than the single Hfetm1.1Nca homozygous mutant





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory