About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hfetm2Nca
targeted mutation 2, Nancy C Andrews
MGI:2385353
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hfetm2Nca/Hfetm2Nca involves: 129S6/SvEvTac MGI:2655482
hm2
 		Hfetm2Nca/Hfetm2Nca involves: 129S6/SvEvTac * C57BL/6J MGI:2655506
ht3
 		Hfetm2Nca/Hfe+ involves: 129S6/SvEvTac MGI:2655483
cx4
 		Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+
Hfetm2Nca/Hfetm2Nca 		involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N MGI:3783643
cx5
 		Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca 		involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca MGI:3578659
cx6
 		Hfetm2Nca/Hfetm2Nca
Tfrctm1Nca/Tfrc+ 		involves: 129S6/SvEvTac MGI:2655487
cx7
 		Hfetm2Nca/Hfetm2Nca
Tg(Ttr-Hfe)1Nca/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:3783645
cx8
 		Hephsla/Hephsla
Hfetm2Nca/Hfetm2Nca 		involves: 129S6/SvEvTac * C57BL/6J MGI:2655486
cx9
 		Hephsla/Y
Hfetm2Nca/Hfetm2Nca 		involves: 129S6/SvEvTac * C57BL/6J MGI:2655488
cx10
 		B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca 		involves: 129S6/SvEvTac * C57BL/6J MGI:2655484
cx11
 		Hfetm2Nca/Hfetm2Nca
Slc11a2mk/Slc11a2mk 		involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ MGI:2655485
cx12
 		Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+ 		involves: C57BL/6J MGI:2687183


Genotype
MGI:2655482
hm1
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:78536 )
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
decreased spleen iron level ( J:78536 )
• decreased splenic iron loading
increased circulating iron level ( J:133221 )
• significant increase in occupancy of serum transferrin with iron
increased liver iron level ( J:62112 , J:133221 )
• increased hepatic iron loading (J:62112)
• increase in liver non-heme iron levels (J:133221)
• deposition of iron is predominantly periportal (J:133221)
• however, at 8 weeks of age no increase in heart iron load is detected compared to wild-type controls (J:133221)

hematopoietic system
decreased spleen iron level ( J:78536 )
• decreased splenic iron loading

immune system
decreased spleen iron level ( J:78536 )
• decreased splenic iron loading

liver/biliary system
increased liver iron level ( J:62112 , J:133221 )
• increased hepatic iron loading (J:62112)
• increase in liver non-heme iron levels (J:133221)
• deposition of iron is predominantly periportal (J:133221)
• however, at 8 weeks of age no increase in heart iron load is detected compared to wild-type controls (J:133221)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:62112 , J:78536




Genotype
MGI:2655506
hm2
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:78536 )
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

hematopoietic system
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

immune system
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:78536




Genotype
MGI:2655483
ht3
Allelic
Composition		 Hfetm2Nca/Hfe+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:62112 )
• increased hepatic iron loading

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading




Genotype
MGI:3783643
cx4
Allelic
Composition		 Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tfrc*)Nca mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating iron level ( J:133221 )
• significant increase in occupancy of serum transferrin with iron
increased liver iron level ( J:133221 )
• increase in liver non-heme iron levels
• this increase is intermediate between that of mice homozygous for Hfetm2Nca or Gt(ROSA)26Sortm1(Tfrc*)Nca alone
• deposition of iron is predominantly periportal

liver/biliary system
increased liver iron level ( J:133221 )
• increase in liver non-heme iron levels
• this increase is intermediate between that of mice homozygous for Hfetm2Nca or Gt(ROSA)26Sortm1(Tfrc*)Nca alone
• deposition of iron is predominantly periportal




Genotype
MGI:3578659
cx5
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic
Background		 involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:98088 )
N
• considerably improved survival

homeostasis/metabolism
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age

hematopoietic system
decreased hematocrit ( J:98088 )
• but improved over condition seen in inSlc11a2 knockout mice

growth/size/body
postnatal growth retardation ( J:98088 )
• body weight considerably better than inSlc11a2 knockout mice at 12 weeks of age

liver/biliary system
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age




Genotype
MGI:2655487
cx6
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Tfrctm1Nca/Tfrc+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Tfrctm1Nca mutation (1 available); any Tfrc mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:3783645
cx7
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Tg(Ttr-Hfe)1Nca/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Tg(Ttr-Hfe)1Nca mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism
decreased circulating iron level ( J:133221 )
• decrease in serum transferrin iron saturation
decreased liver iron level ( J:133221 )
• decrease in stable liver iron compared to wild-type controls

liver/biliary system
decreased liver iron level ( J:133221 )
• decrease in stable liver iron compared to wild-type controls




Genotype
MGI:2655486
cx8
Allelic
Composition		 Hephsla/Hephsla
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephsla mutation (1 available); any Heph mutation (11 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant

digestive/alimentary system
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:2655488
cx9
Allelic
Composition		 Hephsla/Y
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephsla mutation (1 available); any Heph mutation (11 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant

digestive/alimentary system
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:2655484
cx10
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:2655485
cx11
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2mk/Slc11a2mk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Slc11a2mk mutation (2 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:62112 )
• some mice die prior to weaning
• increased viability relative to Slc11a2mk homozygous mutant mice

homeostasis/metabolism
decreased liver iron level ( J:62112 )
• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice

liver/biliary system
decreased liver iron level ( J:62112 )
• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice




Genotype
MGI:2687183
cx12
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
Urodtm1Kush mutation (0 available); any Urod mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased porphyrin level ( J:66704 )
• increased urinary porphyrin concentration (hepatic levels were also increased)

liver/biliary system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
porphyria cutanea tarda DOID:3132 OMIM:176090
OMIM:176100
 J:66704




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory