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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hfetm2Nca
targeted mutation 2, Nancy C Andrews
MGI:2385353
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hfetm2Nca/Hfetm2Nca involves: 129S6/SvEvTac MGI:2655482
hm2
 		Hfetm2Nca/Hfetm2Nca involves: 129S6/SvEvTac * C57BL/6J MGI:2655506
ht3
 		Hfetm2Nca/Hfe+ involves: 129S6/SvEvTac MGI:2655483
cx4
 		Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+
Hfetm2Nca/Hfetm2Nca 		involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N MGI:3783643
cx5
 		Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca 		involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca MGI:3578659
cx6
 		Hfetm2Nca/Hfetm2Nca
Tfrctm1Nca/Tfrc+ 		involves: 129S6/SvEvTac MGI:2655487
cx7
 		Hfetm2Nca/Hfetm2Nca
Tg(Ttr-Hfe)1Nca/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:3783645
cx8
 		Hephsla/Hephsla
Hfetm2Nca/Hfetm2Nca 		involves: 129S6/SvEvTac * C57BL/6J MGI:2655486
cx9
 		Hephsla/Y
Hfetm2Nca/Hfetm2Nca 		involves: 129S6/SvEvTac * C57BL/6J MGI:2655488
cx10
 		B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca 		involves: 129S6/SvEvTac * C57BL/6J MGI:2655484
cx11
 		Hfetm2Nca/Hfetm2Nca
Slc11a2mk/Slc11a2mk 		involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ MGI:2655485
cx12
 		Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+ 		involves: C57BL/6J MGI:2687183


Genotype
MGI:2655482
hm1
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:78536 )
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
decreased spleen iron level ( J:78536 )
• decreased splenic iron loading
increased circulating iron level ( J:133221 )
• significant increase in occupancy of serum transferrin with iron
increased liver iron level ( J:62112 , J:133221 )
• increased hepatic iron loading (J:62112)
• increase in liver non-heme iron levels (J:133221)
• deposition of iron is predominantly periportal (J:133221)
• however, at 8 weeks of age no increase in heart iron load is detected compared to wild-type controls (J:133221)

hematopoietic system
decreased spleen iron level ( J:78536 )
• decreased splenic iron loading

immune system
decreased spleen iron level ( J:78536 )
• decreased splenic iron loading

liver/biliary system
increased liver iron level ( J:62112 , J:133221 )
• increased hepatic iron loading (J:62112)
• increase in liver non-heme iron levels (J:133221)
• deposition of iron is predominantly periportal (J:133221)
• however, at 8 weeks of age no increase in heart iron load is detected compared to wild-type controls (J:133221)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:62112 , J:78536




Genotype
MGI:2655506
hm2
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal iron level ( J:78536 )
• Background Sensitivity: iron loading occurred more rapidly on a 129S6/SvEvTac background than on a mixed background
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

hematopoietic system
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

immune system
decreased spleen iron level ( J:78536 )
• decreased splenic iron load

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:78536




Genotype
MGI:2655483
ht3
Allelic
Composition		 Hfetm2Nca/Hfe+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:62112 )
• increased hepatic iron loading

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading




Genotype
MGI:3783643
cx4
Allelic
Composition		 Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tfrc*)Nca mutation (1 available); any Gt(ROSA)26Sor mutation (985 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating iron level ( J:133221 )
• significant increase in occupancy of serum transferrin with iron
increased liver iron level ( J:133221 )
• increase in liver non-heme iron levels
• this increase is intermediate between that of mice homozygous for Hfetm2Nca or Gt(ROSA)26Sortm1(Tfrc*)Nca alone
• deposition of iron is predominantly periportal

liver/biliary system
increased liver iron level ( J:133221 )
• increase in liver non-heme iron levels
• this increase is intermediate between that of mice homozygous for Hfetm2Nca or Gt(ROSA)26Sortm1(Tfrc*)Nca alone
• deposition of iron is predominantly periportal




Genotype
MGI:3578659
cx5
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic
Background		 involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:98088 )
N
• considerably improved survival

homeostasis/metabolism
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age

hematopoietic system
decreased hematocrit ( J:98088 )
• but improved over condition seen in inSlc11a2 knockout mice

growth/size/body
postnatal growth retardation ( J:98088 )
• body weight considerably better than inSlc11a2 knockout mice at 12 weeks of age

liver/biliary system
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age




Genotype
MGI:2655487
cx6
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Tfrctm1Nca/Tfrc+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
Tfrctm1Nca mutation (1 available); any Tfrc mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:3783645
cx7
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Tg(Ttr-Hfe)1Nca/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
Tg(Ttr-Hfe)1Nca mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism
decreased circulating iron level ( J:133221 )
• decrease in serum transferrin iron saturation
decreased liver iron level ( J:133221 )
• decrease in stable liver iron compared to wild-type controls

liver/biliary system
decreased liver iron level ( J:133221 )
• decrease in stable liver iron compared to wild-type controls




Genotype
MGI:2655486
cx8
Allelic
Composition		 Hephsla/Hephsla
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephsla mutation (1 available); any Heph mutation (11 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant

digestive/alimentary system
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:2655488
cx9
Allelic
Composition		 Hephsla/Y
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephsla mutation (1 available); any Heph mutation (11 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant

digestive/alimentary system
increased intestinal iron level ( J:62112 )
• increased iron loading in the mucosa of the proximal duodenum

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• less hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:2655484
cx10
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (121 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant

liver/biliary system
increased liver iron level ( J:62112 )
• increased hepatic iron loading
• greater hepatic iron loading than than the single Hfetm2Nca homozygous mutant




Genotype
MGI:2655485
cx11
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2mk/Slc11a2mk
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * MK/ReJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
Slc11a2mk mutation (2 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:62112 )
• some mice die prior to weaning
• increased viability relative to Slc11a2mk homozygous mutant mice

homeostasis/metabolism
decreased liver iron level ( J:62112 )
• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice

liver/biliary system
decreased liver iron level ( J:62112 )
• hepatic iron levels similar to those observed in Slc11a2mk homozygous mutant mice




Genotype
MGI:2687183
cx12
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Urodtm1Kush/Urod+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
Urodtm1Kush mutation (0 available); any Urod mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased porphyrin level ( J:66704 )
• increased urinary porphyrin concentration (hepatic levels were also increased)

liver/biliary system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
porphyria cutanea tarda DOID:3132 OMIM:176090
OMIM:176100
 J:66704




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Send questions and comments to User Support. 		last database update
08/02/2024
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