Phenotypes associated with this allele

• Allele Symbol: Mycn^tm2.1Nagy
• Allele Name: targeted mutation 2.1, Andras Nagy
• Allele ID: MGI:2385433
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mycn^tm2.1Nagy/Mycn^tm2.1Nagy	involves: 129S1/Sv * 129X1/SvJ	MGI:2385447
ht2	Mycn^tm2.1Nagy/Mycn^+	involves: 129S1/Sv * 129X1/SvJ	MGI:2385451
ht3	Mycn^tm1Nagy/Mycn^tm2.1Nagy	involves: 129S1/Sv * 129X1/SvJ	MGI:2385449

Genotype
MGI:2385447

hm1

• Allelic Composition: Mycn^tm2.1Nagy/Mycn^tm2.1Nagy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:67930 )

• embryos die at E11.5

Genotype
MGI:2385451

ht2

• Allelic Composition: Mycn^tm2.1Nagy/Mycn⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

limbs/digits/tail

kinked tail ( J:67930 )

• due to vertebral fusions; authors report 25% penetrance in "outbred" background and 100% penetrance in "inbred 129" background

skeleton

vertebral fusion ( J:67930 )

Genotype
MGI:2385449

ht3

• Allelic Composition: Mycn^tm1Nagy/Mycn^tm2.1Nagy
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

neonatal lethality, complete penetrance ( J:67930 )

• animals die at birth

cardiovascular system

abnormal angiogenesis ( J:67930 )

• deficiency of angiogenesis in yolk sac

absent vitelline blood vessels ( J:67930 )

thin myocardium ( J:67930 )

• thin, compact myocardium

embryo

absent vitelline blood vessels ( J:67930 )

decreased embryo size ( J:67930 )

• smaller size apparent by E12.5

pale yolk sac ( J:67930 )

• apparent by E15.5

growth/size/body

decreased embryo size ( J:67930 )

• smaller size apparent by E12.5

respiratory system

abnormal lung development ( J:67930 )

• incomplete lung development

respiratory failure ( J:67930 )

• animals do not breathe after birth

skeleton

abnormal vertebrae morphology ( J:67930 )

• abnormal vertebral column, reduced in length by 40%

abnormal vertebral body development ( J:67930 )

• split ossification of vertebral bodies

small vertebral body ( J:67930 )

• reduced size of vertebral bodies and split ossification

vertebral fusion ( J:67930 )

muscle

thin myocardium ( J:67930 )

• thin, compact myocardium