All Phenotypes Mdm2<tm2.1Glo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm2^tm2.1Glo/Mdm2^tm2.1Glo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2448937
ht2	Mdm2^tm1Glo/Mdm2^tm2.1Glo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2448938
cn3	Mdm2^tm1Glo/Mdm2^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S7/SvEvBrd * FVB/N	MGI:3616710
cn4	Mdm2^tm1Glo/Mdm2^tm2.1Glo Tg(Myh6-cre)2182Mds/0	involves: 129S7/SvEvBrd * FVB/N	MGI:3616709

Allelic Composition	Mdm2^tm2.1Glo/Mdm2^tm2.1Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm2.1Glo mutation (1 available); any Mdm2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:75118 )

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm2.1Glo
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:75118 )

Allelic Composition	Mdm2^tm1Glo/Mdm2^tm2.1Glo Tg(Myh6-cre)2182Mds/0 Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm2^tm2.1Glo mutation (1 available); any Mdm2 mutation (54 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:104114 )

N	• exhibit rescue of the heart lethality seen in conditional Mdm2 mice and have the same life span as single homozygous Trp53 mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104114 )

• all die by E13.5, with abnormalities evident at E9.5 but not E9

growth/size/body

decreased embryo size ( J:104114 )

• smaller than controls, probably due to lack of blood flow, however they develop to the correct developmental stage

cardiovascular system

abnormal heart morphology ( J:104114 )

thin myocardium ( J:104114 )

• significant thinning of the myocardial layer in the ventricles

small heart ( J:104114 )

• heart mass is smaller in E9.5 embryos and by E13.5, most homozygotes lack any visible signs of a heart

abnormal heart ventricle morphology ( J:104114 )

• one of the E13.5 embryos that still has a heart shows abnormal trabeculation in the ventricle and abnormal ventricular wall structure

abnormal cardiovascular system physiology ( J:104114 )

• hearts fail to function properly as indicated by blood leaking outside the heart and the backup of blood in the atrium

abnormal blood circulation ( J:104114 )

• decrease in blood flow that results in congestion and backup of blood in other organs

hemorrhage ( J:104114 )

• exhibit blood leaking outside the heart

muscle

thin myocardium ( J:104114 )

• significant thinning of the myocardial layer in the ventricles

increased cardiomyocyte apoptosis ( J:104114 )

embryo

decreased embryo size ( J:104114 )

• smaller than controls, probably due to lack of blood flow, however they develop to the correct developmental stage

cellular

increased cardiomyocyte apoptosis ( J:104114 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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