All Phenotypes Srf<tm2Nor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Srf^tm2Nor
targeted mutation 2, Alfred Nordheim
MGI:2385464

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srf^tm2Nor/Srf^tm2Nor	involves: 129P2/OlaHsd	MGI:2449176
cn2	Srf^tm2Nor/Srf^tm2Nor Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd	MGI:3843267
cn3	Srf^tm2Nor/Srf^tm2Nor Tg(Cd4-cre)1Cwi/?	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3843265

Allelic Composition	Srf^tm2Nor/Srf^tm2Nor
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srf^tm2Nor mutation (0 available); any Srf mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:75123 )

Allelic Composition	Srf^tm2Nor/Srf^tm2Nor Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Srf^tm2Nor mutation (0 available); any Srf mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:124767 )

• overall reduction of CD19+ B cells in bone marrow

abnormal mature B cell morphology ( J:124767 )

• reduced surface expression of IgM in cells from the spleen, lymph nodes, bone marrow and blood

• surface expression of IgD is not affected

decreased B-1 B cell number ( J:124767 )

• CD19+ IgM+ CD5+ peritoneal B cells are decreased in number

absent marginal zone B cells ( J:124767 )

• in spite of normal follicular architecture

hematopoietic system

decreased B cell number ( J:124767 )

• overall reduction of CD19+ B cells in bone marrow

decreased B-1 B cell number ( J:124767 )

• CD19+ IgM+ CD5+ peritoneal B cells are decreased in number

absent marginal zone B cells ( J:124767 )

• in spite of normal follicular architecture

abnormal mature B cell morphology ( J:124767 )

• reduced surface expression of IgM in cells from the spleen, lymph nodes, bone marrow and blood

• surface expression of IgD is not affected

Allelic Composition	Srf^tm2Nor/Srf^tm2Nor Tg(Cd4-cre)1Cwi/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srf^tm2Nor mutation (0 available); any Srf mutation (27 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:124767 )

• striking decrease on peripheral CD3 T cells

decreased thymocyte number ( J:124767 )

• dramatic 80% reduction of CD4+ thymocytes