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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp63tm3.1Brd
targeted mutation 3.1, Allan Bradley
MGI:2385473
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp63tm3.1Brd/Trp63tm3.1Brd involves: 129S7/SvEvBrd MGI:3798053
cn2
 		Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd 		involves: 129S7/SvEvBrd * FVB * ICR MGI:3798054


Genotype
MGI:3798053
hm1
Allelic
Composition		 Trp63tm3.1Brd/Trp63tm3.1Brd
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3.1Brd mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:100483 )
• when keratinocytes are treated with an adenovirus cre, cellular proliferation is decreased
early cellular replicative senescence ( J:100483 )
• when keratinocytes are treated with an adenovirus cre, cells exhibit premature senescence




Genotype
MGI:3798054
cn2
Allelic
Composition		 Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * FVB * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-cre/PGR)1Der mutation (0 available)
Trp63tm2Brd mutation (1 available); any Trp63 mutation (60 available)
Trp63tm3.1Brd mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
early cellular replicative senescence ( J:100483 )
• following treatment with mifepristonein in utero, mice exhibit an increase in cellular senescence

craniofacial
abnormal craniofacial morphology ( J:100483 )
• at E17.5 following treatment with mifepristonein in utero

limbs/digits/tail
abnormal limb morphology ( J:100483 )
• at E17.5 following treatment with mifepristonein in utero

growth/size/body
weight loss ( J:100483 )
• following treatment with mifepristonein at 8 months of age

skeleton
lordokyphosis ( J:100483 )
• following treatment with mifepristonein at 8 months of age, mice exhibit lordokyphosis that increases with severity as mice age

integument
alopecia ( J:100483 )
• following treatment with mifepristonein at 8 months of age, mice exhibit severe alopecia
abnormal skin morphology ( J:100483 )
• at E17.5 following treatment with mifepristonein in utero or at 8 months of age
abnormal epidermal layer morphology ( J:100483 )
• following treatment with mifepristonein utero, mice exhibit stratified epidermal layer and arrested epidermal morphogenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory