All Phenotypes Fgf17<tm1Dor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf17^tm1Dor
targeted mutation 1, David M Ornitz
MGI:2385594

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf17^tm1Dor/Fgf17^tm1Dor	involves: 129S6/SvEvTac	MGI:3663106
cx2	Fgf8^tm1.4Mrt/Fgf8⁺ Fgf17^tm1Dor/Fgf17^tm1Dor	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:3663107
cx3	Fgf17^tm1Dor/Fgf17^tm1Dor Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl	involves: 129S6/SvEvTac	MGI:4437230

Allelic Composition	Fgf17^tm1Dor/Fgf17^tm1Dor
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf17^tm1Dor mutation (1 available); any Fgf17 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased inferior colliculus size ( J:61429 , J:156717 )

• tissue losses in inferior colliculus (J:61429)

• the tissue between the inferior colliculus and the anterior cerebellum is significantly reduced in adult mice (J:156717)

abnormal Purkinje cell morphology ( J:61429 )

• Purkinje cell migration begins earlier than normal

abnormal cerebellum vermis morphology ( J:61429 )

• overall size of vermis about 82% of control size but hemispheres normal

• decreased cell proliferation in vermis by E12.5

abnormal cerebellum anterior vermis morphology ( J:61429 , J:156717 )

• lobe III of the vermis is partially fused to lobe IV (J:61429)

• lobules I-III are truncated and considerably smaller in size in adult mice (J:156717)

decreased anterior vermis size ( J:61429 )

• lobe III of the vermis is about 1/3 normal size

Allelic Composition	Fgf8^tm1.4Mrt/Fgf8⁺ Fgf17^tm1Dor/Fgf17^tm1Dor
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf17^tm1Dor mutation (1 available); any Fgf17 mutation (35 available)
Fgf8^tm1.4Mrt mutation (0 available); any Fgf8 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased inferior colliculus size ( J:61429 )

• tissue losses in inferior colliculus

abnormal Purkinje cell morphology ( J:61429 )

• Purkinje cell migration begins earlier than normal

abnormal cerebellum vermis morphology ( J:61429 )

• overall size of vermis about 76% of control size but hemispheres normal

• decreased cell proliferation in vermis by E11.5

• neuroepithelium thinner than normal

abnormal cerebellum anterior vermis morphology ( J:61429 )

• lobe III of the vermis is lost by age 2 days and in adults

behavior/neurological

abnormal gait ( J:61429 )

• asymmetrical gait seen in about 20% of mice

Allelic Composition	Fgf17^tm1Dor/Fgf17^tm1Dor Fgf8^tm1.1Jyhl/Fgf8^tm1.1Jyhl
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf17^tm1Dor mutation (1 available); any Fgf17 mutation (35 available)
Fgf8^tm1.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased inferior colliculus size ( J:156717 )

• the tissue between the inferior colliculus and the anterior cerebellum is significantly reduced in adult mice

abnormal cerebellum anterior vermis morphology ( J:156717 )

• lobules I-III are truncated and considerably smaller in size in adult mice

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