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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fen1tm1Rak
targeted mutation 1, Raju Kucherlapati
MGI:2385597
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fen1tm1Rak/Fen1tm1Rak involves: 129/Sv * C57BL/6 * SJL/J MGI:3843878
ht2
 		Fen1tm1Rak/Fen1+ involves: 129/Sv * C57BL/6 * SJL/J MGI:3843880
cx3
 		Fen1tm1Rak/Fen1+
Apctm1Rak/Apc+ 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J MGI:3843881


Genotype
MGI:3843878
hm1
Allelic
Composition		 Fen1tm1Rak/Fen1tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fen1tm1Rak mutation (1 available); any Fen1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:77962 )
• no homozygous pups are detected
• only about half as many homozygous blastocysts as expected are detected in crosses of heterozygous mice




Genotype
MGI:3843880
ht2
Allelic
Composition		 Fen1tm1Rak/Fen1+
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fen1tm1Rak mutation (1 available); any Fen1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus atrophy ( J:77962 )
• heterozygotes are generally viable and fertile with a normal life span
• a small number show thymic atropy and become moribund at 5 or 11 months of age

neoplasm
increased B cell derived lymphoma incidence ( J:77962 )
• some mice found with non-Hodgkin's lymphoma of B cells

digestive/alimentary system
abnormal Paneth cell morphology ( J:77962 )
• one example found of Paneth cell hyperplasia in the small intestine

hematopoietic system
thymus atrophy ( J:77962 )
• heterozygotes are generally viable and fertile with a normal life span
• a small number show thymic atropy and become moribund at 5 or 11 months of age

endocrine/exocrine glands
abnormal Paneth cell morphology ( J:77962 )
• one example found of Paneth cell hyperplasia in the small intestine
thymus atrophy ( J:77962 )
• heterozygotes are generally viable and fertile with a normal life span
• a small number show thymic atropy and become moribund at 5 or 11 months of age




Genotype
MGI:3843881
cx3
Allelic
Composition		 Fen1tm1Rak/Fen1+
Apctm1Rak/Apc+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Rak mutation (1 available); any Apc mutation (158 available)
Fen1tm1Rak mutation (1 available); any Fen1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:77962 )
• median survival of 9 months as compared to 13 months for Apctm1Rak single heterozygotes

neoplasm
increased gastrointestinal tumor incidence ( J:77962 )
• 100% develop gastrointestinal tumors by 1 year of age
increased malignant tumor incidence ( J:77962 )
• incidence of malignant tumors is higher than in Apctm1Rak single heterozygotes

cellular
abnormal cell physiology ( J:77962 )
• extensive microsatellite instability in tumor DNA

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:77962 )
• 100% develop gastrointestinal tumors by 1 year of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory