Phenotypes associated with this allele

• Allele Symbol: Ccnd1^{tm1(CCNE)Pisc}
• Allele Name: targeted mutation 1, Piotr Sicinski
• Allele ID: MGI:2385629
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnd1^tm1(CCNE)Pisc/Ccnd1^tm1(CCNE)Pisc	involves: 129/Sv * C57BL/6	MGI:3844430

Genotype
MGI:3844430

hm1

• Allelic Composition: Ccnd1^{tm1(CCNE)Pisc}/Ccnd1^{tm1(CCNE)Pisc}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:55690 )

N • unlike null mice, postnatal survival is similar to controls

reproductive system

abnormal mammary gland growth during pregnancy ( J:55690 )

♀ • about 30% of females show impaired lobuloalveolar development during pregnancy that is not as severe as in null mice

♀ • about 30% of females show impaired lobuloalveolar development during pregnancy that is as severe as in null mice

♀ • the remainder of females show lobuloalveolar development during pregnancy that is similar to controls

♀ • however, when transplanted into a wild-type host mammary epithelia successfully undergoes lobuloalveolar development during pregnancy

vision/eye

abnormal retina morphology ( J:55690 )

• slight reduction in the number of cells in the retina

abnormal eye electrophysiology ( J:55690 )

• electroretinographic amplitude is about 70% that of controls

behavior/neurological

behavior/neurological phenotype ( J:55690 )

N • unlike null mice, mice do not clasp their legs when lifted by the tail

growth/size/body

growth/size/body region phenotype ( J:55690 )

N • unlike null mice, no growth retardation is seen

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:55690 )

♀ • about 30% of females show impaired lobuloalveolar development during pregnancy that is not as severe as in null mice

♀ • about 30% of females show impaired lobuloalveolar development during pregnancy that is as severe as in null mice

♀ • the remainder of females show lobuloalveolar development during pregnancy that is similar to controls

♀ • however, when transplanted into a wild-type host mammary epithelia successfully undergoes lobuloalveolar development during pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:55690 )

♀ • about 30% of females show impaired lobuloalveolar development during pregnancy that is not as severe as in null mice

♀ • about 30% of females show impaired lobuloalveolar development during pregnancy that is as severe as in null mice

♀ • the remainder of females show lobuloalveolar development during pregnancy that is similar to controls

♀ • however, when transplanted into a wild-type host mammary epithelia successfully undergoes lobuloalveolar development during pregnancy