All Phenotypes Mapt<tm1Hnd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapt^tm1Hnd
targeted mutation 1, Hana N Dawson
MGI:2385630

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapt^tm1Hnd/Mapt^tm1Hnd	involves: 129X1/SvJ * C57BL/6	MGI:3718400
ht2	Mapt^tm1Hnd/Mapt⁺	involves: 129X1/SvJ * C57BL/6	MGI:3718365
cx3	Mapt^tm1Hnd/Mapt^tm1Hnd Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:3718360
cx4	Mapt^tm1Hnd/Mapt⁺ Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:3718361

Allelic Composition	Mapt^tm1Hnd/Mapt^tm1Hnd
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm1Hnd mutation (7 available); any Mapt mutation (430 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice

• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

abnormal axon extension ( J:78649 )

• neuronal cultures from E16 mice show less axonal extension than wild-type neurons; mutant neurons lag behind wild-type in development over initial 2 days in culture, then catch up, but total sum of minor processes/axonal lengths is less than wild-type

abnormal dendrite morphology ( J:78649 )

• between 4 and 7 days in culture, total dendritic length of mutant neurons is less than in wild-type; after 7 days in culture, neurons still lag behind wild-type showing more developmental delay

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice

• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

cellular

abnormal axon extension ( J:78649 )

Allelic Composition	Mapt^tm1Hnd/Mapt⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm1Hnd mutation (7 available); any Mapt mutation (430 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice

• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice

• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

Allelic Composition	Mapt^tm1Hnd/Mapt^tm1Hnd Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm1Hnd mutation (7 available); any Mapt mutation (430 available)
Zbtb20^{Tg(PDGFB-APPSwInd)20Lms} mutation (1 available); any Zbtb20 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:121330 )

N	• mice show normal spatial learning and object-recongition memory, at levels similar to non-transgenic controls • mice show no signs of hyperactivity

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

amyloid beta deposits ( J:121330 )

• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics heterozygous or wild-type for Mapt

abnormal neuron morphology ( J:121330 )

• mice show neuritic dystrophy around amyloid plaques

abnormal neuron differentiation ( J:121330 )

• aberrant sprouting of hippocampal axons is observed in transgenic mice

cellular

abnormal neuron differentiation ( J:121330 )

• aberrant sprouting of hippocampal axons is observed in transgenic mice

homeostasis/metabolism

amyloid beta deposits ( J:121330 )

• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics heterozygous or wild-type for Mapt

Allelic Composition	Mapt^tm1Hnd/Mapt⁺ Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:121330 )

N	• mice show no signs of hyperactivity

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

abnormal spatial learning ( J:121330 )

• in the hidden platform version of the Morris water maze, non-trangenic controls, regardless of Mapt genotype learn the task over 3 days, whereas transgenic mice heterozygous for Mapt^tm1Hnd show show impaired learning compared to controls but less impairment than transgenic mice with normal Mapt expression

• in probe trials where the platform is removed, mice show delayed learning, compared to non transgenic controls or transgenic mice with wild-type Mapt, with more target than non-target crossings after 5 days of training

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

amyloid beta deposits ( J:121330 )

• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt

abnormal neuron morphology ( J:121330 )

• mice show neuritic dystrophy around amyloid plaques

abnormal neuron differentiation ( J:121330 )

• aberrant sprouting of hippocampal axons is observed in transgenic mice

cellular

abnormal neuron differentiation ( J:121330 )

• aberrant sprouting of hippocampal axons is observed in transgenic mice

homeostasis/metabolism

amyloid beta deposits ( J:121330 )

• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt

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