Phenotypes associated with this allele

• Allele Symbol: Tg(Ela1-TAg)18Bri
• Allele Name: transgene insertion 18, Ralph L Brinster
• Allele ID: MGI:2385657
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Epm2a^Tg(TcraK,TcrbK)TG-BFlv/Epm2a^+ Tg(Ela1-TAg)18Bri/0	involves: C57BL/6 * CBA/J * SJL	MGI:3766077
tg2	Tg(Ela1-TAg)18Bri/0	involves: C57BL/6 * SJL	MGI:3766076

Genotype
MGI:3766077

cx1

• Allelic Composition: Epm2a^{Tg(TcraK,TcrbK)TG-BFlv}/Epm2a⁺; Tg(Ela1-TAg)18Bri/0
• Genetic Background: involves: C57BL/6 * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

pancreas inflammation ( J:107545 )

• at 10 weeks, focal perivascular infiltrate is detected

• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate

endocrine/exocrine glands

abnormal pancreas morphology ( J:107545 )

• at 10-12 weeks of age, prominent TAg-induced dysplasia is observed; atypia in cell nuclei and acinar architectural distortion are seen

abnormal exocrine pancreas morphology ( J:107545 )

• pancreas shows exocrine tissue destruction

pancreas inflammation ( J:107545 )

• at 10 weeks, focal perivascular infiltrate is detected

• some 10-20 week-old mice show diffuse immune infiltrate with tissue destruction; animals may show parenchymal infiltrate without tissue destruction or a primarily perivascular infiltrate

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:107545 )

• pancreas shows exocrine tissue destruction

Genotype
MGI:3766076

tg2

• Allelic Composition: Tg(Ela1-TAg)18Bri/0
• Genetic Background: involves: C57BL/6 * SJL

neoplasm

increased pancreas tumor incidence ( J:76995 )

• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors

• 3 islet cell carcinomas develop

increased pancreatic islet cell adenoma incidence ( J:76995 )

• 77% of mice form benign or low-grade islet cell tumors

• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin

increased insulinoma incidence ( J:76995 )

• most islet cell tumors are composed of beta cells

increased pancreatic acinar cell carcinoma incidence ( J:76995 )

endocrine/exocrine glands

abnormal pancreatic acinar cell morphology ( J:76995 )

pancreatic islet hyperplasia ( J:76995 )

increased pancreas tumor incidence ( J:76995 )

• 99% of mice develop pancreatic exocrine tumors concisting of acinar cell carcinoma, undifferentiated carcinoma, cystic carcinoma, and mixed pattern tumors

• 3 islet cell carcinomas develop

increased pancreatic islet cell adenoma incidence ( J:76995 )

• 77% of mice form benign or low-grade islet cell tumors

• most islet cell tumors are composed of beta cells while one expressed predominantly somatostatin

increased insulinoma incidence ( J:76995 )

• most islet cell tumors are composed of beta cells

increased pancreatic acinar cell carcinoma incidence ( J:76995 )

pancreas inflammation ( J:107545 )

• infiltrate localized to perivascular region is detected

immune system

pancreas inflammation ( J:107545 )

• infiltrate localized to perivascular region is detected

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:76995 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:76995