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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxa2tm1Fmr
targeted mutation 1, Filippo M Rijli
MGI:2385689
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxa2tm1Fmr/Hoxa2tm1Fmr involves: 129/Sv * C57BL/6 MGI:3773620
ht2
 		Hoxa2tm1Fmr/Hoxa2+ involves: 129/Sv * C57BL/6 MGI:3773618


Genotype
MGI:3773620
hm1
Allelic
Composition		 Hoxa2tm1Fmr/Hoxa2tm1Fmr
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa2tm1Fmr mutation (0 available); any Hoxa2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:80131 )
• mice die at three weeks of age

craniofacial
abnormal styloid process morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the styloid process
abnormal hyoid bone lesser horn morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the lesser horns of the hyoid bone
abnormal stapes morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the stapes

growth/size/body
postnatal growth retardation ( J:80131 )

hearing/vestibular/ear
abnormal stapes morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the stapes

nervous system
abnormal rhombomere 2 morphology ( J:80131 )
• segmentation and patterning of rhombomere 2 is disrupted as determined by marker expression patterns
• however, patterning of rhombomere 3 is normal

skeleton
abnormal styloid process morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the styloid process
abnormal hyoid bone lesser horn morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the lesser horns of the hyoid bone
abnormal stapes morphology ( J:80131 )
• at E18.5, some mice exhibit unilateral abnormalities in the stapes

embryo
abnormal rhombomere 2 morphology ( J:80131 )
• segmentation and patterning of rhombomere 2 is disrupted as determined by marker expression patterns
• however, patterning of rhombomere 3 is normal




Genotype
MGI:3773618
ht2
Allelic
Composition		 Hoxa2tm1Fmr/Hoxa2+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa2tm1Fmr mutation (0 available); any Hoxa2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:80131 )
• mice display no abnormal phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory